Seth A. Bennett
City University of New York
8 Papers
Seth A. Bennett is an academic researcher from City University of New York. The author has contributed to research in topics: Histone & Biology. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Seth A. Bennett include Brooklyn College.
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Papers
Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease.
TL;DR: Both local and global changes in histone modification profiles are associated with ALS drawing attention to potential targets for future diagnostic and treatment approaches.
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Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes.
Karen Chen,Seth A. Bennett,Navin Rana,Huda Yousuf,Mohamed Mohamed Tolba Said,Sadiqa Taaseen,Natalie Mendo,Steven Marc Meltser,Mariana P. Torrente +8 more
TL;DR: In this article, the authors comprehensively delineate histone post-translational modification (PTM) profiles in ALS and PD yeast proteinopathy models, and find that the histone inclusions formed by the RNA-binding proteins TDP-43 and FUS are most notable in ALS, while α-synuclein aggregates into Lewy bodies in PD.
Trichostatin A Relieves Growth Suppression and Restores Histone Acetylation at Specific Sites in a FUS ALS/FTD Yeast Model.
Seth A. Bennett,Seth A. Bennett,Samantha N. Cobos,Samantha N. Cobos,Melagras Mirzakandova,Michel Fallah,Elizaveta Son,George Angelakakis,Navin Rana,Muna M Hugais,Mariana P. Torrente,Mariana P. Torrente +11 more
TL;DR: In this article, the authors showed that inhibiting histone deacetylases, via treatment with trichostatin A, suppresses the toxicity associated with FUS overexpression in yeast by preserving the levels of H3K56ac and H3k14ac without affecting the expression or aggregation of FUS.
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[PRION+] States Are Associated with Specific Histone H3 Post-Translational Modification Changes
Samantha N. Cobos,Chaim Janani,Gabriel Cruz,Navin Rana,Elizaveta Son,Rania Frederic,Jailene Paredes Casado,Maliha Khan,Seth A. Bennett,Mariana P. Torrente +9 more
TL;DR: In this paper , the histone H3 modification landscape in the context of the [SWI+] and [PIN+] prion states was mapped to histone post-translational modifications.
Mapping Out Histone Post‐Translational Modifications in a Yeast Prion Model
Samantha N. Cobos,Elizaveta Son,Jailene Paredes,Navin Rana,Seth A. Bennett,Mariana P. Torrente +5 more
TL;DR: Here, it is effectively shown that the yeast epigenome is directly linked to prion states, further confirming the role of prions as another form of epigenetic modulation.