Sergio E. Alvarez
National University of San Luis
27 Papers
47 Citations
Sergio E. Alvarez is an academic researcher from National University of San Luis. The author has contributed to research in topics: Sphingosine kinase 1 & Sphingosine kinase. The author has an hindex of 14, co-authored 26 publications. Previous affiliations of Sergio E. Alvarez include Virginia Commonwealth University & VCU Medical Center.
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Papers
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Sergio E. Alvarez,Kuzhuvelil B. Harikumar,Nitai C. Hait,Jeremy C. Allegood,Graham M. Strub,Eugene Y. Kim,Michael Maceyka,Hualiang Jiang,Cheng Luo,Tomasz Kordula,Sheldon Milstien,Sarah Spiegel +11 more
TL;DR: The data show that TRAF2 is a novel intracellular target of S1p, and that S1P is the missing cofactor for TRAF 2 E3 ubiquitin ligase activity, indicating a new paradigm for the regulation of lysine-63-linked polyubiquitination.
Autocrine and paracrine roles of sphingosine-1-phosphate
TL;DR: This review summarizes recent findings on the roles of S1P as a mediator of the actions of cytokines, growth factors and hormones.
308
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation
Sravan K. Goparaju,Puneet S. Jolly,Puneet S. Jolly,Kenneth R. Watterson,Meryem Bektas,Sergio E. Alvarez,Sukumar Sarkar,Lin Mel,Isao Ishii,Jerold Chun,Sheldon Milstien,Sarah Spiegel +11 more
TL;DR: It is found that cross-communication between platelet-derived growth factor receptor and S1P2 serves as a negative damper of PDGF functions, suggesting that a complex interplay between PDGFR and S 1P receptors determines their functions.
137
Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion
Dai Shida,Xianjun Fang,Tomasz Kordula,Kazuaki Takabe,Sandrine Lépine,Sergio E. Alvarez,Sheldon Milstien,Sarah Spiegel +7 more
TL;DR: The results suggest that SphK1 is a convergence point of multiple cell surface receptors for three different ligands, LPA, EGF, and S1P, which have all been implicated in regulation of motility and invasiveness of cancer cells.
136
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions
Carole A. Oskeritzian,Sergio E. Alvarez,Nitai C. Hait,Megan M. Price,Sheldon Milstien,Sarah Spiegel +5 more
TL;DR: The data suggest that differential formation of S1P by SphK1 and SphK2 has distinct and important actions in hMCs, as determined by specifically down-regulating their expression.
129