Sergio Candel
University of Murcia
30 Papers
2 Citations
Sergio Candel is an academic researcher from University of Murcia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 14 publications.
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Papers
Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response
Sofia de Oliveira,Sofia de Oliveira,Constantino Carlos Reyes-Aldasoro,Sergio Candel,Stephen A. Renshaw,Victoriano Mulero,Ângelo Calado +6 more
TL;DR: The zebrafish is confirmed as an excellent in vivo model to shed light on the roles of CXCL8 in neutrophil biology and is suggested to possess a subpopulation of neutrophils whose recruitment to inflamed areas occurs independently of Cxcl8 chemokines.
344
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Raquel Espín-Palazón,Raquel Espín-Palazón,David L. Stachura,Clyde Campbell,Diana García-Moreno,Natasha Del Cid,Albert D. Kim,Sergio Candel,José Meseguer,Victoriano Mulero,David Traver +10 more
TL;DR: It is demonstrated that proinflammatory signaling, in the absence of infection, is utilized by the developing embryo to generate the lineal precursors of the adult hematopoietic system.
317
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
Sylwia D. Tyrkalska,Sylwia D. Tyrkalska,Sergio Candel,Diego Angosto,Victoria Gómez-Abellán,Fátima Martín-Sánchez,Diana García-Moreno,Rubén Zapata-Pérez,Álvaro Sánchez-Ferrer,María P. Sepulcre,Pablo Pelegrín,Victoriano Mulero +11 more
TL;DR: Zebrafish guanylate-binding protein 4 (Gbp4), an IFNγ-inducible GTPase protein harbouring a C-terminal CARD domain, is required for the inflammasome-dependent clearance of Salmonella Typhimurium (ST) by neutrophils in vivo.
Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress–Induced Inflammation
Sergio Candel,Sofia de Oliveira,Sofia de Oliveira,Azucena López-Muñoz,Diana García-Moreno,Raquel Espín-Palazón,Sylwia D. Tyrkalska,Sylwia D. Tyrkalska,María L. Cayuela,Stephen A. Renshaw,Raúl Corbalán-Vélez,Inmaculada Vidal-Abarca,Huai-Jen Tsai,José Meseguer,María P. Sepulcre,Victoriano Mulero +15 more
TL;DR: A new zebrafish model of skin inflammatory disease explains new-onset and worsening psoriasis and lichen planus in patients receiving anti-TNFα therapy.
TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response.
Raquel Espín-Palazón,A. Martinez-Lopez,Francisco J. Roca,Azucena López-Muñoz,Sylwia D. Tyrkalska,Sergio Candel,Diana García-Moreno,Alberto Falco,José Meseguer,Amparo Estepa,Victoriano Mulero +10 more
TL;DR: This results demonstrate that Tnfa signals through its receptor Tnfr2 to enhance viral replication and provides new therapeutic targets for the treatment of SVCV-infected fish, and advances the understanding of the previously enigmatic deleterious role of TNFα in certain viral infections.