KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases

https://digital.csic.es/bitstream/10261/149461/1/Kidney%20International%202016.pdf

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases.

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy - dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) - have overlapping clinical and pathological features suggestive of a disease continuum. Dysregulation of the complement alternative pathway is fundamental to the manifestations of C3 glomerulopathy, although terminal pathway dysregulation is also common. Disease is driven by acquired factors in most patients - namely, autoantibodies that target the C3 or C5 convertases. These autoantibodies drive complement dysregulation by increasing the half-life of these vital but normally short-lived enzymes. Genetic variation in complement-related genes is a less frequent cause. No disease-specific treatments are available, although immunosuppressive agents and terminal complement pathway blockers are helpful in some patients. Unfortunately, no treatment is universally effective or curative. In aggregate, the limited data on renal transplantation point to a high risk of disease recurrence (both DDD and C3GN) in allograft recipients. Clinical trials are underway to test the efficacy of several first-generation drugs that target the alternative complement pathway.

/pdf/c3-glomerulopathy-understanding-a-rare-complement-driven-otb20tefo7.pdf

C3 glomerulopathy — understanding a rare complement-driven renal disease

Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

https://www.kidney-international.org/article/S0085-2538(15)60998-X/pdf

Effectiveness of mycophenolate mofetil in C3 glomerulonephritis

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Effectiveness of mycophenolate mofetil in C3 glomerulonephritis