Sergei E. Permyakov
Russian Academy of Sciences
95 Papers
380 Citations
Sergei E. Permyakov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Chemistry & Recoverin. The author has an hindex of 20, co-authored 75 publications. Previous affiliations of Sergei E. Permyakov include California Polytechnic State University.
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Papers
Apo-parvalbumin as an intrinsically disordered protein
Sergei E. Permyakov,Anush G. Bakunts,Alexander I. Denesyuk,Alexander I. Denesyuk,Ekaterina L. Knyazeva,Vladimir N. Uversky,Vladimir N. Uversky,Eugene A. Permyakov +7 more
TL;DR: It is shown that apo‐state of pike parvalbumin and β‐isoforms belongs to the family of IDP, which is in accord with theoretical predictions, and that PA in apo-state is essentially disordered nevertheless demonstrates complex denaturation behavior.
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Generic structures of cytotoxic liprotides: nano-sized complexes with oleic acid cores and shells of disordered proteins.
Jørn Døvling Kaspersen,Jannik Nedergaard Pedersen,Jon Gade Hansted,Jon Gade Hansted,Søren B. Nielsen,Søren B. Nielsen,Srinivasan Sakthivel,Kristina Wilhelm,Kristina Wilhelm,Ekaterina L. Nemashkalova,Sergei E. Permyakov,Eugene A. Permyakov,Cristiano L. P. Oliveira,Ludmilla A. Morozova-Roche,Daniel E. Otzen,Jan Skov Pedersen +15 more
TL;DR: A new, generic structural model of cytotoxic protein–oleic acid complexes is presented, which is termed liprotides (lipids and partially denatured proteins) and is consistent with a cargo off‐loading of the OA into cell membranes.
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Tuning of a neuronal calcium sensor.
Oliver H. Weiergräber,Ivan I. Senin,Eugene Yu Zernii,Valeriya A. Churumova,Nadezhda A. Kovaleva,Aliya A. Nazipova,Sergei E. Permyakov,Eugene A. Permyakov,Pavel P. Philippov,Joachim Granzin,Karl-Wilhelm Koch +10 more
TL;DR: A novel role of the C-terminal segment of recoverin as an internal modulator of Ca2+ sensitivity is proposed, based on observations of changes in average coordinates compared with wild-type recoverin and strong indication of increased conformational flexibility.
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Effects of mutations in the calcium-binding sites of recoverin on its calcium affinity: evidence for successive filling of the calcium binding sites.
Sergei E. Permyakov,Alexandra M. Cherskaya,Ivan I. Senin,Aminullah A. Zargarov,Sergey V. Shulga-Morskoy,A. M. Alekseev,Dmitry V. Zinchenko,Valery M. Lipkin,Pavel P. Philippov,Vladimir N. Uversky,Eugene A. Permyakov +10 more
TL;DR: It is suggested that the binding of calcium ions to recoverin is a sequential process with the EF-hand 3 being filled first.
The Use of Human, Bovine, and Camel Milk Albumins in Anticancer Complexes with Oleic Acid
Esmail M. El-Fakharany,Marwa M. Abu-Serie,Ekaterina A. Litus,Sergei E. Permyakov,Eugene A. Permyakov,Vladimir N. Uversky,Vladimir N. Uversky,Vladimir N. Uversky,Elrashdy M. Redwan +8 more
TL;DR: The interaction of OA with albumins isolated from human, bovine, and camel milk results in the formation of complexes with high antitumor activity against Caco- 2, HepG-2, PC-3, and MCF-7 tumor cells, suggesting that albumins have the potential to be used as efficient and low cost means of tumor treatment.
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