Sergei E. Permyakov
Russian Academy of Sciences
95 Papers
380 Citations
Sergei E. Permyakov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Chemistry & Recoverin. The author has an hindex of 20, co-authored 75 publications. Previous affiliations of Sergei E. Permyakov include California Polytechnic State University.
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Papers
Natively unfolded C-terminal domain of caldesmon remains substantially unstructured after the effective binding to calmodulin.
Sergei E. Permyakov,Ian S. Millett,Sebastian Doniach,Eugene A. Permyakov,Vladimir N. Uversky,Vladimir N. Uversky +5 more
TL;DR: It is shown here that CaD136 does not have globular structure, has low secondary structure content, is essentially noncompact, and is characterized by the absence of distinct heat absorption peaks, i.e. it belongs to the family of natively unfolded (or intrinsically unstructured) proteins.
115
Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches.
Evgeni Yu. Zernii,Viktoriia E. Baksheeva,Elena N. Iomdina,Olga A. Averina,Sergei E. Permyakov,Pavel P. Philippov,Andrey A. Zamyatnin,Ivan I. Senin +7 more
TL;DR: Clinical, morphological and mechanistic aspects of the most common ocular diseases (dry eye syndrome, glaucoma, age-related macular degeneration, light-induced retinopathies, cataract and uveitis) are described and the diversity of current strategies for their experimental modeling in rabbits are summarized.
100
Who Is Mr. HAMLET? Interaction of Human α-Lactalbumin with Monomeric Oleic Acid†
Ekaterina L. Knyazeva,Valery M. Grishchenko,R. S. Fadeev,Vladimir S. Akatov,Sergei E. Permyakov,Eugene A. Permyakov +5 more
TL;DR: The fact that the HAMLET-like complex can be formed in aqueous solution makes the process of its preparation more transparent and controllable, opening up opportunities for formation of active complexes with specific properties.
82
Oleic acid is a key cytotoxic component of HAMLET-like complexes
Sergei E. Permyakov,Ekaterina L. Knyazeva,Leysan M. Khasanova,R. S. Fadeev,Andrei P. Zhadan,Hazeline Roche-Hakansson,Anders Håkansson,Vladimir S. Akatov,Eugene A. Permyakov +8 more
TL;DR: Overall, the proteinaceous component of HAMLET-like complexes studied is not a prerequisite for their activity; the cytotoxicity of these complexes is mostly due to the action of OA.
71
Two Structural Motifs within Canonical EF-Hand Calcium-Binding Domains Identify Five Different Classes of Calcium Buffers and Sensors
Konstantin Denessiouk,Sergei E. Permyakov,Alexander I. Denesyuk,Eugene A. Permyakov,Mark S. Johnson +4 more
TL;DR: Two highly-conserved structural motifs are described, which provide a supporting scaffold for the DxDxDG calcium binding loop and contribute to the hydrophobic core of the EF hand domain, which allow more precise identification of calcium buffers and calcium sensors.