Serge Alfos
University of Bordeaux
24 Papers
183 Citations
Serge Alfos is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Retinoic acid & Retinoid X receptor. The author has an hindex of 15, co-authored 22 publications. Previous affiliations of Serge Alfos include Institut national de la recherche agronomique.
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Papers
Retinoic Acid Restores Adult Hippocampal Neurogenesis and Reverses Spatial Memory Deficit in Vitamin A Deprived Rats
Emilie Bonnet,Katia Touyarot,Serge Alfos,Véronique Pallet,Paul Higueret,Djoher Nora Abrous,Djoher Nora Abrous +6 more
TL;DR: It is demonstrated for the first time that the effect of vitamin A deficient diet on the level of hippoccampal neurogenesis is reversible and that RA treatment is important for the maintenance of the hippocampal plasticity and function.
Age-related decreases in mRNA for brain nuclear receptors and target genes are reversed by retinoic acid treatment
V Enderlin,Véronique Pallet,Serge Alfos,Elise Dargelos,Robert Jaffard,Henri Garcin,Paul Higueret +6 more
TL;DR: It is hypothesized that a decrease in the cellular action of RA and T3 could play a role, via a decreases in the expression of RC3, in the alteration of synaptic plasticity occurring in aged mice.
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Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats
Marianne Husson,V Enderlin,André Delacourte,Nadirah Ghenimi,Serge Alfos,Véronique Pallet,Paul Higueret +6 more
TL;DR: The results suggest that fine regulation of vitamin A mediated gene expression seems fundamental for the regulation of APP processing.
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Differential effect of retinoic acid and triiodothyronine on the age-related hypo-expression of neurogranin in rat
Catherine Féart,F. Mingaud,V Enderlin,Marianne Husson,Serge Alfos,Paul Higueret,Véronique Pallet +6 more
TL;DR: During aging, T3 become a limiting factor alone able to correct the age-related concomitant hypo-activation of retinoid and thyroid signalings and alterations of synaptic plasticity.
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Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids
V Enderlin,Serge Alfos,Véronique Pallet,Henri Garcin,V Azaı̈s-Braesco,Robert Jaffard,Paul Higueret +6 more
TL;DR: In the brain of aged rats, there was a lower abundance of TR and RAR mRNA and a lower activity of tissue transglutaminase (tTG), an enzyme the gene of which is a target for retinoids.
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