Serena Muratcioglu
Koç University
21 Papers
53 Citations
Serena Muratcioglu is an academic researcher from Koç University. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 12, co-authored 18 publications. Previous affiliations of Serena Muratcioglu include University of California, Berkeley & California Institute for Quantitative Biosciences.
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Papers
Ras Conformational Ensembles, Allostery, and Signaling.
Shaoyong Lu,Shaoyong Lu,Hyunbum Jang,Serena Muratcioglu,Attila Gursoy,Ozlem Keskin,Ruth Nussinov,Ruth Nussinov,Jian Zhang +8 more
TL;DR: This review focuses on data that have accumulated over the past few years pertaining to the conformational ensembles and the allosteric regulation of Ras proteins and their interpretation from a conformational landscape standpoint.
323
GTP-Dependent K-Ras Dimerization
Serena Muratcioglu,Tanmay S. Chavan,Benjamin C. Freed,Hyunbum Jang,Lyuba Khavrutskii,R. Natasha Freed,Marzena A. Dyba,Karen Stefanisko,Sergey G. Tarasov,Attila Gursoy,Ozlem Keskin,Nadya I. Tarasova,Vadim Gaponenko,Ruth Nussinov,Ruth Nussinov +14 more
TL;DR: The data reveal how Ras self-association can regulate effector binding and activity, and suggest that disruption of the helical dimer interface by drugs may abate Raf signaling in cancer.
210
Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers
TL;DR: Collectively, Ras isoforms' dimer conformations are not uniform; instead, the isoform-specific dimers reflect the favoured interactions of the HVRs with cell membrane microdomains, biasing the effector-binding site orientations, thus isoform binding selectivity.
96
The structural network of Interleukin-10 and its implications in inflammation and cancer.
Ece Saliha Acuner-Ozbabacan,H. Billur Engin,Emine Guven-Maiorov,Guray Kuzu,Serena Muratcioglu,Alper Baspinar,Zhong Chen,Carter Van Waes,Attila Gursoy,Ozlem Keskin,Ruth Nussinov,Ruth Nussinov +11 more
TL;DR: The results suggest that mutations that disrupt the interactions of IL-10 with its receptors and α2-macroglobulin and A2M may enhance inflammation and modulate anti-tumor immunity and the structural data of protein complexes suggest how oncogenic mutations influence the interactions and explain their potential impact onIL-10 signaling in cancer and inflammation.
Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation
TL;DR: Key among them is the concentration of calcium/calmodulin, negative feedback loops, where a downstream member of the pathway inhibits its upstream activator and cross-inhibition, where inhibition entails blocking another pathway.
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