Serena Montanari
University of Bologna
22 Papers
9 Citations
Serena Montanari is an academic researcher from University of Bologna. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 9, co-authored 15 publications. Previous affiliations of Serena Montanari include University of Parma & University of Aberdeen.
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Papers
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer’s Disease Agents
Serena Montanari,Laura Scalvini,Manuela Bartolini,Federica Belluti,Silvia Gobbi,Vincenza Andrisano,Alessia Ligresti,Vincenzo Di Marzo,Silvia Rivara,Marco Mor,Alessandra Bisi,Angela Rampa +11 more
TL;DR: Among the two series of synthesized compounds, compounds 9 and 19 were identified as effective dual FAAH/ChE inhibitors, with well-balanced nanomolar activities, and might be considered as new promising candidates for Alzheimer's disease treatment.
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Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease
Angela De Simone,Valeria La Pietra,Nibal Betari,Nicola Petragnani,Mariarosaria Conte,Simona Daniele,Deborah Pietrobono,Claudia Martini,Sabrina Petralla,Raffaella Casadei,Lara Davani,F. Frabetti,Pasquale Russomanno,Ettore Novellino,Serena Montanari,Vincenzo Tumiatti,Patrizia Ballerini,Federica Sarno,Angela Nebbioso,Lucia Altucci,Barbara Monti,Vincenza Andrisano,Andrea Milelli +22 more
TL;DR: The discovery and the biochemical characterization of the first-in-class hit compound able to exert promising anti-AD effects by modulating the targeted proteins in the low micromolar range of concentration is presented.
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Serena Montanari,Ali M. Mahmoud,Letizia Pruccoli,Alessandro Rabbito,Marina Naldi,Sabrina Petralla,Ignacio Moraleda,Manuela Bartolini,Barbara Monti,Isabel Iriepa,Federica Belluti,Silvia Gobbi,Vincenzo Di Marzo,Alessandra Bisi,Andrea Tarozzi,Alessia Ligresti,Angela Rampa +16 more
TL;DR: A small library of newly designed 2-arylbenzofuran derivatives was evaluated towards cholinesterases and cannabinoid receptors and the two most promising compounds, 8 and 10, were assessed for their neuroprotective activity and for their ability to modulate the microglial phenotype.
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Dry powders for the inhalation of ciprofloxacin or levofloxacin combined with a mucolytic agent for cystic fibrosis patients.
Yagmur Akdag Cayli,Selma Sahin,Francesca Buttini,Anna Giulia Balducci,Serena Montanari,Imran Vural,Levent Öner +6 more
TL;DR: Together, these methods showed that these methods could suitably characterize antibiotic and mucolytic-containing dry powder inhalers.
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Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer
Elena Catanzaro,Nibal Betari,Jose M. Arencibia,Serena Montanari,Claudia Sissi,Angela De Simone,Ivano Vassura,Alan Santini,Vincenza Andrisano,Vincenzo Tumiatti,Marco De Vivo,Dmitri V. Krysko,Marco B. L. Rocchi,Carmela Fimognari,Andrea Milelli +14 more
TL;DR: The discovery of a new topoII inhibitor, whose design was based on the structure of the natural product trypthantrin, a natural alkaloid containing a basic indoloquinazoline moiety, which represents a promising lead for developing newTopoII inhibitors as anti-cancer therapeutic agents.
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