Serap Yilmaz
Ankara University
16 Papers
60 Citations
Serap Yilmaz is an academic researcher from Ankara University. The author has contributed to research in topics: Docking (molecular) & Topoisomerase. The author has an hindex of 7, co-authored 14 publications. Previous affiliations of Serap Yilmaz include Trakya University.
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Papers
Synthesis and biological evaluation of 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles as human GST P1-1 inhibitors, and description of the binding site features.
Tugba Ertan-Bolelli,Yaman Musdal,Kayhan Bolelli,Serap Yilmaz,Yasemin Aksoy,Ilkay Yildiz,Esin Aki-Yalcin,Ismail Yalcin +7 more
TL;DR: The design and synthesis of some novel sulfonamide‐containing benzoxazoles, which are able to inhibit human GST P1‐1 are reported, and 2‐(4‐chlorobenzyl)‐5‐ (4‐nitrophenylsulfonamido)benzoxazole (5 f) was found as the most active hGST P 1‐1 inhibitor, with an IC50 value of 10.2 μM, showing
30
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo IIα
Esin Karatas,Egemen Foto,Tugba Ertan-Bolelli,Gozde Yalcin-Ozkat,Serap Yilmaz,Sanaz Ataei,Fatma Zilifdar,Ilkay Yildiz +7 more
TL;DR: In this article, the authors designed and synthesized some 5 or 6-nitro-2-(substitutedphenyl)benzoxazole derivatives as novel candidate antitumor agents targeting human DNA topoisomerase enzymes (hTopo I and hTopo IIα).
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Binding site feature description of 2-substituted benzothiazoles as potential AcrAB-TolC efflux pump inhibitors in E. coli.
Serap Yilmaz,G. Altinkanat-Gelmez,Kayhan Bolelli,D. Guneser-Merdan,M. Ufuk Over-Hasdemir,Esin Aki-Yalcin,Ismail Yalcin +6 more
TL;DR: A set of BSN-coded 2-substituted benzothiazoles tested alone and in combinations with ciprofloxacin against the AcrAB-TolC overexpressor Escherichia coli AG102 clinical strain indicated that the BSN compounds did not show intrinsic antimicrobial activity when tested alone, but when used in combination with CIP, a reversal in the antibacterial activity of CIP was observed.
19
Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives
Fatma Zilifdar,Sabiha Alper-Hayta,Serap Yilmaz,Çiğdem Kaplan-Özen,Egemen Foto,Zeliha Aydoğan,Ilkay Yildiz,Esin Aki,Ismail Yalcin,Nuran Diril +9 more
TL;DR: Experimental data showed genotoxic potentials and inhibitory effects on eukaryotic DNA topoisomerase I of 16 newly synthesized benzoxazine derivatives and the most active compounds, BS18 and BS4, showed higher inhibitory activities than the positive control drug camptothecin which is a well-known commercial topoisomersase I inhibitor.
Generated 3D-common feature hypotheses using the HipHop method for developing new topoisomerase I inhibitors.
TL;DR: From this research, it can be suggested that the ligand‐based three‐dimensional pharmacophore model could be useful for further studies in order to design new potent Topo I‐targeting antitumor drugs.