Serah Choi
University of Pittsburgh
29 Papers
135 Citations
Serah Choi is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: DNA damage & Biology. The author has an hindex of 14, co-authored 19 publications. Previous affiliations of Serah Choi include University of California, San Francisco.
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Papers
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress
Wei Qian,Serah Choi,Gregory A. Gibson,Simon C. Watkins,Christopher J. Bakkenist,Bennett Van Houten +5 more
TL;DR: It is demonstrated that the inhibition of mitochondrial fission protein Drp1 causes an unexpected delay in G2/M cell cycle progression and aneuploidy, a novel mechanism that contributes to the cellular dysfunction and diseases associated with altered mitochondrial dynamics.
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Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation
Julie P. Goff,Donna Shields,Mineaki Seki,Serah Choi,Michael W. Epperly,Tracy Dixon,Hong Wang,Christopher J. Bakkenist,Stephen D. Dertinger,Dorothea K. Torous,John P. Wittschieben,Richard D. Wood,Joel S. Greenberger +12 more
TL;DR: The sensitivity of POLQ-defective bone marrow stromal cells to ionizing radiation and bleomycin and the increase in micronuclei in red blood cells support a role for this DNA polymerase in cellular tolerance of DNA damage that can lead to double-strand DNA breaks.
Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.
TL;DR: It is proposed that an essential, yet previously undescribed, role for ATM kinase in suppressing chromosomal instability is revealed and it is suggested that irreversible chromosome damage accumulates very rapidly when ATM Kinase activity is transiently inhibited following irradiation.
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Intraesophageal Manganese Superoxide Dismutase-Plasmid Liposomes Ameliorates Novel Total-Body and Thoracic Radiation Sensitivity of NOS1-/- Mice
Malolan S. Rajagopalan,Brandon Stone,Jean-Claude M. Rwigema,Umar Salimi,Michael W. Epperly,Julie P. Goff,Darcy Franicola,Tracy Dixon,Shaonan Cao,Xichen Zhang,Bettina M. Buchholz,Anthony J. Bauer,Serah Choi,Christopher J. Bakkenist,Hong Wang,Joel S. Greenberger +15 more
TL;DR: In NOS1−/− mice, MnSOD-PL significantly increased survival after both thoracic and total-body irradiation, and may be related to the developmental esophageal enteric neuronal innervation abnormalities described in these mice.
Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes
Serah Choi,Rohith Srivas,Katherine Y. Fu,Brian L. Hood,Banu Dost,Gregory A. Gibson,Simon C. Watkins,Bennett Van Houten,Nuno Bandeira,Thomas P. Conrads,Trey Ideker,Christopher J. Bakkenist +11 more
TL;DR: A role for ATM kinase activity in the dynamic exchange of proteins in DDR complexes is revealed and a role for ANXA1 in cellular radioprotection is identified.
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