Seppo Ylä-Herttuala
University of Eastern Finland
849 Papers
7K Citations
Seppo Ylä-Herttuala is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Medicine & Angiogenesis. The author has an hindex of 76, co-authored 810 publications. Previous affiliations of Seppo Ylä-Herttuala include University of California, San Diego & University of Jyväskylä.
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Papers
Low density lipoprotein undergoes oxidative modification in vivo
Wulf Palinski,Michael E. Rosenfeld,Seppo Ylä-Herttuala,Geoff C. Gurtner,Steve S. Socher,Susan Butler,Sampath Parthasarathy,Thomas E. Carew,Daniel Steinberg,Joseph L. Witztum +9 more
TL;DR: Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.
Autoantibody against oxidised LDL and progression of carotid atherosclerosis.
Jukka T. Salonen,Seppo Ylä-Herttuala,Yamamoto R,Susan Butler,H. Korpela,Riitta Salonen,Kristiina Nyyssönen,Wulf Palinski,Joseph L. Witztum +8 more
TL;DR: The titre of autoantibodies to MDA-LDL was an independent predictor of the progression of carotid atherosclerosis in these Finnish men, providing further support for a role of oxidatively modified LDL in atherogenesis.
1.3K
Biology of vascular endothelial growth factors
TL;DR: The biology of VEGFs is reviewed and their role in pathological angiogenesis and lymphangiogenesis is evaluated.
877
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Taija Makinen,Lotta Jussila,Tanja Veikkola,Terhi Karpanen,Mikko I. Kettunen,Kalevi J. Pulkkanen,Risto A. Kauppinen,David A. Jackson,Hajime Kubo,Shin-Ichi Nishikawa,Seppo Ylä-Herttuala,Kari Alitalo +11 more
TL;DR: It is shown that a soluble form of VEGFR-3 is a potent inhibitor of Vascular endothelial growth factor (VEGF)-C and VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal.
849
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
Tatiana V. Petrova,Taija Makinen,Tomi P. Mäkelä,Janna Saarela,Ismo Virtanen,Robert E. Ferrell,David N. Finegold,Dontscho Kerjaschki,Seppo Ylä-Herttuala,Kari Alitalo +9 more
TL;DR: It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs.