Seok-Geun Lee
Kyung Hee University
135 Papers
294 Citations
Seok-Geun Lee is an academic researcher from Kyung Hee University. The author has contributed to research in topics: Signal transduction & Apoptosis. The author has an hindex of 39, co-authored 132 publications. Previous affiliations of Seok-Geun Lee include Catholic University of Korea & Seoul National University.
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Papers
Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma.
TL;DR: It is suggested that ophiopogonin D can induce apoptosis and exert anti-tumor effects by inhibition of STAT3 signaling pathways in NSCLC.
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Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
Yunu Jung,Jinbong Park,Hye-Lin Kim,Jung-Eun Sim,Dong-Hyun Youn,JongWook Kang,Seona Lim,Mi-Young Jeong,Woong Mo Yang,Seok-Geun Lee,Kwang Seok Ahn,Jae-Young Um +11 more
TL;DR: Results suggest that vanillic acid has potential as an AMPKα‐ and thermogenesis‐activating antiobesity agent and in vivo and in vitro.
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GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy
Yongjin Yoo,Jane Jung,Yoo Na Lee,Youngha Lee,Hyosuk Cho,Eunjung Na,Jea Yeok Hong,Eun Jin Kim,Jin Sook Lee,Je Sang Lee,Chansik Hong,Sang-Yoon Park,Jinhong Wie,Kathryn G. Miller,Natasha Shur,Cheryl Clow,Roseànne S. Ebel,Suzanne D. DeBrosse,Lindsay B. Henderson,Rebecca Willaert,Christopher Castaldi,Irina Tikhonova,Kaya Bilguvar,Shrikant Mane,Ki Joong Kim,Yong Seung Hwang,Seok-Geun Lee,Insuk So,Byung Chan Lim,Hee Jung Choi,Jae Young Seong,Yong Beom Shin,Hosung Jung,Jong Hee Chae,Murim Choi +34 more
TL;DR: This work investigated the specific molecular mechanism that allows an understanding of the pathogenesis and relationship of these two conditions, RTT andEE.
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Ceramide Plays a Prominent Role in MDA-7/IL-24-Induced Cancer-Specific Apoptosis
Moira Sauane,Zao-Zhong Su,Rupesh Dash,Xiang Liu,James S. Norris,Devanand Sarkar,Seok-Geun Lee,Jeremy C. Allegood,Paul Dent,Sarah Spiegel,Paul B. Fisher +10 more
TL;DR: Ceramide is defined as a key mediator of an ER stress pathway that may underlie mda‐7/IL‐24 induction of cancer‐specific killing.
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Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
Seung Ho Baek,Jong Hyun Lee,Chulwon Kim,Jeong-Hyeon Ko,Seung-Hee Ryu,Seok-Geun Lee,Woong Mo Yang,Jae-Young Um,Arunachalam Chinnathambi,Sulaiman Ali Alharbi,Gautam Sethi,Gautam Sethi,Gautam Sethi,Kwang Seok Ahn +13 more
TL;DR: Overall, GAC 17:1 was found to abrogate STAT3 signaling pathway and thus exert its anticancer effects against multiple myeloma cells.
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