Sejin Lee
Yonsei University
24 Papers
57 Citations
Sejin Lee is an academic researcher from Yonsei University. The author has contributed to research in topics: Protein aggregation & Taurine. The author has an hindex of 10, co-authored 24 publications. Previous affiliations of Sejin Lee include Korea University of Science and Technology & Korea Institute of Science and Technology.
Chat about Author
Papers
Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice
Seung-Hoon Yang,Dongkeun K. Lee,Jisu Shin,Sejin Lee,Sejin Lee,Seungyeop Baek,Seungyeop Baek,Jiyoon Kim,Jiyoon Kim,Hoyong Jung,Jung Mi Hah,Young-Soo Kim +11 more
TL;DR: It is found that an anti‐necroptotic molecule necrostatin‐1 (Nec‐1) directly targets Aβ and tau proteins, alleviates brain cell death and ameliorates cognitive impairment in AD models.
142
Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease
Hye Yun Kim,Hyunjin Vincent Kim,Jin Ho Yoon,Bo Ram Kang,Soo Min Cho,Sejin Lee,Jiyoon Kim,Joo Won Kim,Yakdol Cho,Jiwan Woo,Young-Soo Kim +10 more
TL;DR: Results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages in AD.
Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.
Yoosoo Yang,Jaewook Kim,Jaewook Kim,Hye Yun Kim,Nayeon Ryoo,Sejin Lee,Young-Soo Kim,Hyewhon Rhim,Hyewhon Rhim,Yeon-Kyun Shin,Yeon-Kyun Shin +10 more
TL;DR: It is reported that intracellular amyloid-β (Aβ) oligomers directly inhibit SNARE-mediated exocytosis by impairing SNARE complex formation, likely leading to AD-associated synaptic dysfunctions.
74
A highly sensitive plasma-based amyloid-β detection system through medium-changing and noise cancellation system for early diagnosis of the Alzheimer's disease.
Yong Kyoung Yoo,Yong Kyoung Yoo,Jinsik Kim,Gangeun Kim,Young-Soo Kim,Hye Yun Kim,Sejin Lee,Won Woo Cho,Seong-Soo Kim,Sang Myung Lee,Byung Chul Lee,Jeong Hoon Lee,Kyo Seon Hwang +12 more
TL;DR: The results confirmed the potential of this system to discriminate between patients and healthy controls, which would enable blood-based AD diagnosis, and the medium change was optimized in relation to the absolute value of impedance change and differentiated impedance changes for real plasma based Aβ detection.
Fibroblast culture on surface-modified poly (glycolide-co-ε-caprolactone) scaffold for soft tissue regeneration
Il Keun Kwon,Keehyun Park,Sung Won Choi,Sejin Lee,Eun Bae Lee,J. S. Na,Sunpil Kim,Yong Hee Kim +7 more
TL;DR: It is demonstrated that surface-modified PGCL scaffold can provide a suitable substrate for fibroblast culture, especially in the case of soft tissue regenerations.
41