Seiya Kitamura
Scripps Research Institute
39 Papers
66 Citations
Seiya Kitamura is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Chemistry & Epoxide hydrolase 2. The author has an hindex of 9, co-authored 26 publications. Previous affiliations of Seiya Kitamura include Torrey Pines Institute for Molecular Studies & Kyoto University.
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Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Qinheng Zheng,Jordan L. Woehl,Seiya Kitamura,Diogo Santos-Martins,Christopher J. Smedley,Gencheng Li,Stefano Forli,John E. Moses,Dennis W. Wolan,K. Barry Sharpless +9 more
TL;DR: Evaluation of the ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed a selective and covalent hNE inhibitor: benzene-1,2-disulfonyl fluoride.
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Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
Seiya Kitamura,Qinheng Zheng,Jordan L. Woehl,Angelo Solania,Emily I. Chen,Nicholas Dillon,Mitchell V. Hull,Miyako Kotaniguchi,John R. Cappiello,Shinichi Kitamura,Victor Nizet,K. Barry Sharpless,Dennis W. Wolan +12 more
TL;DR: A high-throughput hit-to-lead process based on the biocompatible SuFEx click chemistry that succeeds on picomole scale for direct screening and can accelerate the development of robust biological probes and drug candidates is demonstrated.
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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Christopher J. Smedley,Gencheng Li,Andrew S. Barrow,Timothy L Gialelis,Marie-Claire Giel,Alessandra Ottonello,Yunfei Cheng,Seiya Kitamura,Dennis W. Wolan,K. Barry Sharpless,John E. Moses,John E. Moses +11 more
TL;DR: This work showcases 2- S ubstituted- A lkynyl-1- S ulfonyl F luorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes and reports a diverse click-library of 173 unique functional molecules in minimal synthetic steps.
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Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
Elizabeth N. Bess,Elizabeth N. Bess,Jordan E. Bisanz,Fauna Yarza,Annamarie Bustion,Barry E. Rich,Xingnan Li,Seiya Kitamura,Emily Waligurski,Qi Yan Ang,Diana L. Alba,Peter Spanogiannopoulos,Stephen Nayfach,Suneil K. Koliwad,Dennis W. Wolan,Adrian A. Franke,Peter J. Turnbaugh +16 more
TL;DR: A consortium of four human gut microbiota species, including Eggerthella lenta, can convert plant-derived lignans into bioactive enterolignans via a five-step pathway, providing mechanistic insight into the production of these protective metabolites.
Discovery of small-molecule enzyme activators by activity-based protein profiling
Bernard P. Kok,Srijana Ghimire,Woojoo Kim,Shreyosree Chatterjee,Tyler Johns,Seiya Kitamura,Jerome Eberhardt,Daisuke Ogasawara,Janice H Xu,Ara Sukiasyan,Sean M. Kim,C. Godio,Julia M. Bittencourt,Michael D. Cameron,Andrea Galmozzi,Stefano Forli,Dennis W. Wolan,Benjamin F. Cravatt,Dale L. Boger,Enrique Saez +19 more
TL;DR: Activity-based protein profiling was used to identify and optimize bioactive, selective pharmacological enzyme activators of the serine hydrolase LYPLAL1, which improved the metabolic defects of diet-induced obese mice and is suggested that ABPP may aid discovery of activators for additional enzyme classes.
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