Seiji Takeuchi
Kobe University
21 Papers
181 Citations
Seiji Takeuchi is an academic researcher from Kobe University. The author has contributed to research in topics: Xeroderma pigmentosum & Nucleotide excision repair. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Seiji Takeuchi include Osaka University.
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Papers
Mutational analysis of a function of xeroderma pigmentosum group A (XPA) protein in strand-specific DNA repair
Takehiro Kobayashi,Seiji Takeuchi,Masafumi Saijo,Yoshimichi Nakatsu,Hiroshi Morioka,Eiko Otsuka,Mitsuo Wakasugi,Osamu Nikaido,Kiyoji Tanaka +8 more
TL;DR: The results indicate that the XPA protein is equally important for the C PD repair in both transcribed and non-transcribed strands and that the R207G mutation found in XP129 may not be responsible for a selective defect in CPD repair in the non- transcribed strand in XP 129.
•Journal Article
Strand Specificity and Absence of Hot Spots for p53 Mutations in Ultraviolet B-induced Skin Tumors of XPA-deficient Mice
Seiji Takeuchi,Yoshimichi Nakatsu,Hironobu Nakane,Hiroaki Murai,Seiichi Hirota,Yukihiko Kitamura,Akihiko Okuyama,Kiyoji Tanaka +7 more
TL;DR: XPA-deficient mice showed significant mutation features that might be characteristic of the absence of nucleotide excision repair and may provide a good animal model for the analysis of the high incidence of skin cancer in xeroderma pigmentosum group A patients.
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Characteristics of Xeroderma Pigmentosum in Japan: Lessons From Two Clinical Surveys and Measures for Patient Care.
Chikako Nishigori,Eiji Nakano,Taro Masaki,Ryusuke Ono,Seiji Takeuchi,Mariko Tsujimoto,Takehiro Ueda +6 more
TL;DR: The frequency of skin cancers in patients with XP has decreased in these 20 years, and the age of onset of developing skin cancers is higher than those previously observed, owing to early diagnosis and education to patients and care takers on strict prevention from sunlight.
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UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency.
Kiyoji Tanaka,Shinya Kamiuchi,Yan Ren,Rie Yonemasu,Minoru Ichikawa,Hiroaki Murai,Masafumi Yoshino,Seiji Takeuchi,Masafumi Saijo,Yoshimichi Nakatsu,Hiroko Miyauchi-Hashimoto,Takeshi Horio +11 more
TL;DR: It is possible that an enhanced impairment of the immune system by UVB irradiation is involved in the high incidence of skin cancer in XP and the role of NER in the mutagenesis induced by various carcinogens is analysed.
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Fas/APO-1-mediated apoptosis of human renal cell carcinoma.
Norio Nonomura,Tsuneharu Miki,Masayoshi Yokoyama,Tetsuo Imazu,Tsuyoshi Takada,Seiji Takeuchi,Nobufumi Kanno,Kazuo Nishimura,Yasuyuki Kojima,Akihiko Okuyama +9 more
TL;DR: Investigation of Fas-mediated apoptosis of cultured human renal cell carcinoma THE AUTHORS'-10 and immunohistochemical analysis of resected tissues from the patients with renal cancer revealed stronger expression of Fas antigen on the surface of cancer cells than that of normal cells, suggesting Fas may be one of the possible targets for a novel approach to human kidney cancer.
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