Seiichi Uesugi
Yokohama National University
6 Papers
62 Citations
Seiichi Uesugi is an academic researcher from Yokohama National University. The author has contributed to research in topics: Hydrogen bond & Aptamer. The author has an hindex of 5, co-authored 6 publications.
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Papers
Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics.
Youhei Miyanoiri,Hisanori Kobayashi,Takao Imai,Michinao Watanabe,Takashi Nagata,Seiichi Uesugi,Hideyuki Okano,Masato Katahira +7 more
TL;DR: Comparative studies have revealed the origin of the higher affinity of RBD1 than that of R BD2 and indicated that the affinity of an RBD to RNA is not governed by its fold alone but is also determined by its surface electrostatic potential and/or backbone dynamics.
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Method for direct discrimination of intra- and intermolecular hydrogen bonds, and characterization of the G(:A):G(:A):G(:A):G heptad, with scalar couplings across hydrogen bonds
Hidetsugu Sotoya,Akimasa Matsugami,Tetsuro Ikeda,Kiyoshi Ouhashi,Seiichi Uesugi,Masato Katahira +5 more
TL;DR: The method has been validated with a symmetric dimer of d(GGGCTTTTGGGC), for which the structure including both intra- and intermolecular hydrogen bonds was already reported and demonstrated that the method can clearly discriminate these two kinds of hydrogen bonds.
Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance
Yoshiaki Enokizono,Akimasa Matsugami,Seiichi Uesugi,Hirokazu Fukuda,Naoto Tsuchiya,Takashi Sugimura,Minako Nagao,Hitoshi Nakagama,Masato Katahira +8 more
- 01 Sep 2003
TL;DR: It is demonstrated that hnRNP A1 destroys the quadruplex of Pc-1 on binding and abrogates the arrest of DNA polymerase at the repeat and suggests the involvement of these proteins in telomere maintenance as DNA chaperons.
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RNA and DNA, which contain two GGAGG segments connected with UUUU or TTTT sequences, form entirely different quadruplex structures
Seiichi Uesugi,Hui Liu,Atsushi Kugimiya,Akimasa Matsugami,Masato Katahira +4 more
- 01 Sep 2003
TL;DR: The solution structure of d(GGAGGTTTTTT GGAGG) (D14) in the presence of Na+ ions by NMR is determined, which is entirely different from that of r(GG AGGUUUUGGAGg) (R14), which has been previously determined by N MR.
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Structure of RNA aptamer for HIV Tat complexed with Tat-derived peptide.
Akimasa Matsugami,Yusuke Tamura,Michiko Kudo,Seiichi Uesugi,Rika Yamamoto,Penmetcha K. R. Kumar,Masato Katahira +6 more
- 01 Nov 2004
TL;DR: The profile of chemical sift perturbations for the aptamer upon complex formation with RKKRR revealed that RKK RR can be a realistic analogue of Tat to address the interactions between the arginine-rich motif of Tat and the aptafer.