Sei Kobayashi
Yamaguchi University
29 Papers
457 Citations
Sei Kobayashi is an academic researcher from Yamaguchi University. The author has contributed to research in topics: Rho-associated protein kinase & Vascular smooth muscle. The author has an hindex of 16, co-authored 29 publications. Previous affiliations of Sei Kobayashi include Kyushu University.
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Papers
Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation
Yasuko Kureishi,Sei Kobayashi,Mutsuki Amano,Kazushi Kimura,Hideo Kanaide,Takeshi Nakano,Kozo Kaibuchi,Masaaki Ito +7 more
TL;DR: It is demonstrated that Rho-kinase directly modulates smooth muscle contraction through myosin light chain phosphorylation, independently of the Ca2+-calmodulin-dependent myos in light chain kinase pathway.
628
Eicosapentaenoic acid (EPA) induces Ca2+‐independent activation and translocation of endothelial nitric oxide synthase and endothelium‐dependent vasorelaxation
Masato Omura,Sei Kobayashi,Yoichi Mizukami,Kimiko Mogami,Natsuko Todoroki-Ikeda,Teruki Miyake,Masunori Matsuzaki +6 more
TL;DR: EPA induces Ca2+‐independent activation and translocation of eNOS and endothelium‐dependent vasorelaxation in endothelial cells in situ and induced endothelia‐dependent relaxation of bovine coronary arteries precontracted with U46619.
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Nuclear Mitogen-activated Protein Kinase Activation by Protein Kinase Cζ during Reoxygenation after Ischemic Hypoxia
Yoichi Mizukami,Sei Kobayashi,Florian Überall,Karina Hellbert,Nobuyuki Kobayashi,Ken-ichi Yoshida +5 more
TL;DR: Observations indicate that PKCζ, which is activated by phosphoinositide 3-kinase, induces MAPK activation through MEK in the nucleus during reoxygenation after ischemic hypoxia.
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Orphan G Protein-coupled Receptor, GPR41, Induces Apoptosis via a p53/Bax Pathway during Ischemic Hypoxia and Reoxygenation
Masayasu Kimura,Yoichi Mizukami,Toshiro Miura,Kiyoko Fujimoto,Sei Kobayashi,Masunori Matsuzaki +5 more
TL;DR: It is demonstrated that GPR41 is a novel receptor that activates p53 leading to apoptosis during reoxygenation after ischemic hypoxia in H9c2 cells, which is designated as the Hypoxia-induced apoptosis receptor, HIA-R.
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Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders
Takashi Ohama,Masatoshi Hori,Eiichi Momotani,Yoichiro Iwakura,Fengling Guo,Hiroko Kishi,Sei Kobayashi,Hiroshi Ozaki +7 more
TL;DR: The findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha plays a central role in this process.
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