Sean Ott
University of California, Davis
10 Papers
26 Citations
Sean Ott is an academic researcher from University of California, Davis. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 7 publications.
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Papers
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts
Saeid Ghavami,Saeid Ghavami,Behzad Yeganeh,Amir A. Zeki,Shahla Shojaei,Nicholas J. Kenyon,Sean Ott,Afshin Samali,John B. Patterson,Javad Alizadeh,Javad Alizadeh,Adel Rezaei Moghadam,Adel Rezaei Moghadam,Ian M.C. Dixon,Helmut Unruh,Darryl A. Knight,Martin Post,Thomas Klonisch,Andrew J. Halayko,Andrew J. Halayko +19 more
TL;DR: The IRE1 arm of the UPR response is uniquely induced by TGF-β1 in lung fibroblasts from human IPF donors and is required for excessive biosynthesis of collagen and fibronectin in these cells.
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SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19
Danielle Beckman,Alyssa C. Bonillas,Giovanne B. Diniz,Sean Ott,Jamin W. Roh,Sonny R. Elizaldi,Brian A. Schmidt,Rebecca L. Sammak,Koen K. A. Van Rompay,Smita S. Iyer,John Morris +10 more
TL;DR: In this article , the authors investigated whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated by aging in a non-human primate model of COVID-19.
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Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung‐targeted approach to deliver statins
Amir A. Zeki,Jennifer M. Bratt,Kevin Y. Chang,Lisa M. Franzi,Sean Ott,Mark Silveria,Oliver Fiehn,Oliver Fiehn,Nicholas J. Kenyon +8 more
TL;DR: It is shown that pravastatin is quantifiable in tissues, achieves high levels in mouse lungs with minimal systemic absorption, and mitigates some pathological features of allergic asthma.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of α-tocopherol deficient mice
Vihas T. Vasu,Sean Ott,Brad A. Hobson,Vania Rashidi,Saji Oommen,Carroll E. Cross,Kishorchandra Gohil +6 more
TL;DR: The transcriptome of ataxic muscles from α-tocopherol transfer protein deficient, ATTP-KO mice was compared with that of their normal littermates and genes encoding sarcolipin and ubiquitin carboxyl-terminal hydrolase were over-expressed, suggesting over-expression of sln and uchl1 may also contribute to AT-sensitive ataxia in humans.
Inhibition of myeloperoxidase: Evaluation of 2H-indazoles and 1H-indazolones
Aaron Roth,Sean Ott,Kelli M. Farber,Teresa A. Palazzo,Wayne E. Conrad,Makhluf J. Haddadin,Dean J. Tantillo,Carroll E. Cross,Jason P. Eiserich,Mark J. Kurth +9 more
TL;DR: A structure-activity relationship study was undertaken wherein compounds were evaluated utilizing taurine-chloramine and MPO-mediated H2O2 consumption assays and 14 compounds were found to be potent inhibitors with IC50 values <1μM, suggesting these compounds could be considered as potential modulators of pro-oxidative tissue injury pertubated by the inflammatory MPO/H2O 2/HOCl/HOBr system.
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