Seamas C. Donnelly
Trinity College, Dublin
222 Papers
1.9K Citations
Seamas C. Donnelly is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Medicine & Macrophage migration inhibitory factor. The author has an hindex of 47, co-authored 192 publications. Previous affiliations of Seamas C. Donnelly include University of Texas Health Science Center at Tyler & Western General Hospital.
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Papers
MIF signal transduction initiated by binding to CD74.
Lin Leng,Christine N. Metz,Yan Ju Fang,Jing-Jing Xu,Seamas C. Donnelly,John A. Baugh,Thomas Delohery,Yibang Chen,Robert A. Mitchell,Richard Bucala +9 more
TL;DR: It is reported herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF, and it is identified as a natural ligand forCD74, which has been implicated previously in signaling and accessory functions for immune cell activation.
1.1K
Peripheral blood fibrocytes differentiation pathway and migration to wound sites
TL;DR: In this paper, a method for producing fibrocytes comprising contacting a population of human peripheral blood mononuclear cells (PBMC) comprising predominantly CD14+ cells with autologous T cells or a form of TGFs, preferably TGF-s1, was described.
977
Diastolic Heart Failure Evidence of Increased Myocardial Collagen Turnover Linked to Diastolic Dysfunction
Ramon Martos,John A. Baugh,Mark Ledwidge,C. O'Loughlin,C. Conlon,A Patle,Seamas C. Donnelly,Kenneth McDonald +7 more
TL;DR: Serological evidence of an active fibrotic process in DHF is demonstrated, which is more marked in more severe phases of diastolic dysfunction, as well as new avenues for diagnostic and therapeutic intervention.
498
•Journal Article
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.
Toshiya Atsumi,Jason Chesney,Christine N. Metz,Lin Leng,Seamas C. Donnelly,Zenji Makita,Robert F. Mitchell,Richard Bucala +7 more
TL;DR: It is reported that the expression of iPFK-2 mRNA and protein, as assessed by in situ hybridization and immunohistochemistry, is increased in many human cancers when compared with corresponding normal tissues and may serve as an essential regulator of glycolysis during cell cycle progression and growth in an hypoxic microenvironment.
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