Scott Wasdo
University of Florida
24 Papers
342 Citations
Scott Wasdo is an academic researcher from University of Florida. The author has contributed to research in topics: Transdermal & Solubility. The author has an hindex of 13, co-authored 23 publications.
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Papers
Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation.
Kevin W. Powers,Scott C. Brown,Vijay B. Krishna,Scott Wasdo,Brij M. Moudgil,Stephen M. Roberts +5 more
TL;DR: Recommendations regarding how best to approach nanomaterial characterization include using proper sampling and measurement techniques, forming multidisciplinary teams, and making measurements as close to the biological action point as possible.
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Designing for topical delivery: Prodrugs can make the difference
Kenneth B. Sloan,Scott Wasdo +1 more
TL;DR: Several equations (transformed Potts–Guy or Series/Parallel) have been developed which include aqueous solubility (SAQ) as a parameter for predicting flux through skin and show, for parent drugs delivered by prodrugs from IPM in vitro through hairless mouse skin, that watersolubility is almost as important as lipid solubilty.
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Design for optimized topical delivery: Prodrugs and a paradigm change.
TL;DR: A new working paradigm is necessary to explain the experimental data, and arguments for its use in the design of new prodrugs or in the selection of candidate analogs or homologs for commercialization are argued.
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Topical Delivery of 5-Fluorouracil and 6-Mercaptopurine by Their Alkylcarbonyloxymethyl Prodrugs from Water: Vehicle Effects on Design of Prodrugs
Kenneth B. Sloan,Scott Wasdo,Udo Ezike-Mkparu,Thomas L. Murray,Donna Nickels,Surjit Singh,Thea Shanks,John M. Tovar,Karen Ulmer,Robert P. Waranis +9 more
TL;DR: The transformed Potts-Guy equation can be used to predict JMAQ but with less certainty than JMIPM, with a balance between the two solubilities being obviously important.
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The effect of water solubility of solutes on their flux through human skin in vitro.
TL;DR: The Flynn database for determining the effect of the physicochemical properties of solutes on their skin absorption has been edited to give a database for which the solubilities of the solutes in water, S(AQ), and their maximum fluxes from water through human skin in vitro, J(MAQ), are known or can be calculated.
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