Scott P. Heximer
Washington University in St. Louis
6 Papers
Scott P. Heximer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Heterotrimeric G protein & RGS2. The author has an hindex of 6, co-authored 6 publications.
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Papers
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
K. Mary Tang,Guang-rong Wang,Ping Lu,Richard H. Karas,Mark Aronovitz,Scott P. Heximer,Kevin M. Kaltenbronn,Kendall J. Blumer,David P. Siderovski,Yan Zhu,Michael E. Mendelsohn +10 more
TL;DR: It is shown that RGS-2 is required for normal vascular function and blood pressure and is a new drug development target for hypertension.
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Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice
Scott P. Heximer,Russell H. Knutsen,Xiaoguang Sun,Kevin M. Kaltenbronn,Man Hee Rhee,Ning Peng,Antonio J. Oliveira-dos-Santos,Josef M. Penninger,Anthony J. Muslin,Thomas H. Steinberg,J. Michael Wyss,Robert P. Mecham,Kendall J. Blumer +12 more
TL;DR: It is established that abnormally prolonged signaling by G protein-coupled vasoconstrictor receptors can contribute to the onset of hypertension, and it is suggested that genetic defects affecting the function or expression of RGS2 may be novel risk factors for development of hypertension in humans.
Mechanisms governing subcellular localization and function of human RGS2.
TL;DR: A conserved N-terminal domain in RGS2 is identified and characterized that is necessary and sufficient for plasma membrane localization and may serve as a scaffold that binds receptors, signaling proteins, or nuclear components.
137
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency
Gilles Faury,Mylène Pezet,Russell H. Knutsen,Walter A. Boyle,Scott P. Heximer,Sean E. McLean,Robert K. Minkes,Kendall J. Blumer,Attila Kovacs,Daniel P. Kelly,Dean Y. Li,Barry Starcher,Robert P. Mecham +12 more
TL;DR: Physiological studies indicate a role for the renin-angiotensin system in maintaining the hypertensive state and strongly suggests that elastin and other proteins of the elastic fiber should be considered as causal genes for essential hypertension.
RGS2/G0S8 is a selective inhibitor of Gqα function
TL;DR: The results identify a clear physiological role for RGS2, and describe the first example of an RGS protein that is a selective inhibitor of Gqα function, which is 10-fold more potent than RGS4 in blocking Gq α-directed activation of phospholipase Cβ1 in cell membranes.