Scott K. Smith
Merck & Co.
26 Papers
274 Citations
Scott K. Smith is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemistry & DNA gyrase. The author has an hindex of 13, co-authored 26 publications.
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Papers
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
John W. Phillips,Michael A. Goetz,Scott K. Smith,Deborah L. Zink,Jon D. Polishook,Russell Onishi,Scott P. Salowe,Judyann Wiltsie,John J. Allocco,Janet M. Sigmund,Karen Dorso,Suzy Lee,Stephen Skwish,Mercedes de la Cruz,Jesús Martín,Francisca Vicente,Olga Genilloud,Jun Lu,Ronald E. Painter,Katherine Young,Karen M. Overbye,Robert G. K. Donald,Sheo B. Singh +22 more
TL;DR: Kibdelomycin is the first truly novel bacterial type II topoisomerase inhibitor with potent antibacterial activity discovered from natural product sources in more than six decades.
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Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.
Craig A. Parish,Scott K. Smith,Kathleen Calati,Deborah L. Zink,Kenneth E. Wilson,Terry Roemer,Bo Jiang,Deming Xu,Gerald F. Bills,Gonzalo Platas,Fernando Pelaez,Maria Teresa Diez,Nancy N. Tsou,Arlene E. Mckeown,Richard G. Ball,Mary Ann Powles,Lai Yeung,Paul A. Liberator,Guy H. Harris +18 more
TL;DR: Parnafungins demonstrated broad spectrum antifungal activity with no observed activity against gram-positive or gram-negative bacteria.
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Biosynthesis of nodulisporic acid A: precursor studies.
TL;DR: A novel pathway for the biosynthesis of NAA involves the acetate/mevalonic acid pathway leading to geranylgeranyl pyrophosphate (GGPP), which is then proposed to condense with tryptophan to form the basic indole-diterpene core.
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Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum.
Craig A. Parish,Mercedes de la Cruz,Scott K. Smith,Deborah L. Zink,Jenny M. Baxter,Samantha Tucker-Samaras,Javier Collado,Gonzalo Platas,Gerald F. Bills,Maria Teresa Diez,Francisca Vicente,Fernando Pelaez,Kenneth E. Wilson +12 more
TL;DR: An extract of Geomyces pannorum was identified as providing increased activity against the sensitized strain as compared with the wild-type control, andBioassay-guided isolation of the active component from this fungal extract provided a new cis-decalin secondary metabolite, which is named pannomycin.
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Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.
Kithsiri Herath,Guy H. Harris,Hiranthi Jayasuriya,Deborah L. Zink,Scott K. Smith,Francisca Vicente,Gerald F. Bills,Javier Collado,Antonio Gonzalez,Bo Jiang,Jennifer Nielsen Kahn,Stefan Galuska,Robert A. Giacobbe,George K. Abruzzo,Emily Hickey,Paul A. Liberator,Deming Xu,Terry Roemer,Sheo B. Singh +18 more
TL;DR: The purified compound contains a 28 member ring consisting of eight amino acids and a beta-hydroxy-gamma-methyl-hexadecanoic acid, and displays a broad spectrum of antifungal activity against Candida spp.
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