Scott J. Snipas
Discovery Institute
62 Papers
720 Citations
Scott J. Snipas is an academic researcher from Discovery Institute. The author has contributed to research in topics: Caspase & Proteases. The author has an hindex of 31, co-authored 54 publications. Previous affiliations of Scott J. Snipas include Sanford-Burnham Institute for Medical Research & Duke University.
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Papers
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
3.1K
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
Patrick Mehlen,Shahrooz Rabizadeh,Shahrooz Rabizadeh,Scott J. Snipas,Scott J. Snipas,Nuria Assa-Munt,Nuria Assa-Munt,Guy S. Salvesen,Guy S. Salvesen,Dale E. Bredesen,Dale E. Bredesen +10 more
TL;DR: Results indicate that DCC may function as a tumour-suppressor protein by inducing apoptosis in settings in which ligand is unavailable through functional caspase cascades by a mechanism that requires cleavage of DCC at Asp 1,290.
446
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repurposing.
429
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Sabrina Sofia Burgener,Nathan Georges François Leborgne,Scott J. Snipas,Guy S. Salvesen,Phillip I. Bird,Charaf Benarafa +5 more
TL;DR: It is demonstrated that cytosolic serpins expressed in myeloid cells prevent cell death and regulate inflammatory responses by inhibiting CatG and alternative activation of GSDMD.
235
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Qiao Zhou,Joseph F. Krebs,Scott J. Snipas,Annamarie Price,Emad S. Alnemri,Kevin J. Tomaselli,Guy S. Salvesen +6 more
TL;DR: P35 is an active-site-directed inhibitor highly adapted to inhibiting caspases, verified by demonstrating that purified recombinant p35 inhibits human caspase-1, -3, -6, -7, -8, and -10 with kass values from 1.2 x 10(3) to 7x 10(5) (M-1 s-1), and with upper limits of Ki values from 0.1 to 9 nM.
216