Scott Grindrod
Georgetown University Medical Center
24 Papers
90 Citations
Scott Grindrod is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 10, co-authored 17 publications. Previous affiliations of Scott Grindrod include Georgetown University & Colgate University.
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Papers
Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.
Shujie Hou,Yong Weon Yi,Hyo Jin Kang,Li Zhang,Hee Jeong Kim,Yali Kong,Yong Liu,Kan Wang,Hye-Sik Kong,Scott Grindrod,Insoo Bae,Milton L. Brown +11 more
TL;DR: In vitro and in vivo studies showed that the inhibitory effects of 12 on phospho-STAT3 were through up-regulation of the protein-tyrosine phosphatase PTPN6, strongly support the continued preclinical evaluation of compound 12 as a potential chemotherapeutic agent for TNBC and cancers with constitutive STAT3 signaling.
Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
Yali Kong,Mira Jung,Kan Wang,Scott Grindrod,Alfredo Velena,Sung A. Lee,Sivanesan Dakshanamurthy,Yonghong Yang,Matthew Miessau,Chaoyi Zheng,Anatoly Dritschilo,Milton L. Brown +11 more
TL;DR: Observations support a mechanism by which nuclear histone acetylation is increased as a result of HDAC4 trapping and sequestration in the cytoplasm after binding to compound 2.
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Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft.
Kathryn D. Sheikh,Partha P. Banerjee,Shankar Jagadeesh,Scott Grindrod,Li Zhang,Mikell Paige,Milton L. Brown +6 more
TL;DR: A fluorescent lead compound up-regulated RASSF1A in vitro, potently inhibited human prostate cancer cell proliferation, and fluoresced at a visible wavelength, allowing for the observation of intracellular distribution.
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Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells.
Venkata Mahidhar Yenugonda,Tushar B. Deb,Scott Grindrod,Sivanesan Dakshanamurthy,Yonghong Yang,Mikell Paige,Milton L. Brown +6 more
TL;DR: Two new fluorescent CDK inhibitors are designed and synthesized based on a purvalanol B scaffold and showed undiminished activity in multidrug resistance (MDR) positive breast cancer cells, indicating that they are not a substrate for p-glycoprotein.
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Synthesis of C-Glycoside Analogues of β-Galactosamine-(1–>4)-3-O-Methyl-D-Chiro-Inositol and Assay as Activator of Protein Phosphatases PDHP and PP2Cα
Sunej Hans,Fatoumata Camara,Fatoumata Camara,Ahmad S. Altiti,Ahmad S. Altiti,Alejandro Martin-Montalvo,David L. Brautigan,D. B. Heimark,Joseph Larner,Scott Grindrod,Milton L. Brown,David R. Mootoo,David R. Mootoo +12 more
TL;DR: It is suggested that INS-2 binds to distinctive sites on the two different phosphatases to activate insulin signaling, and the carbon analog could selectively favor glucose disposal via oxidative pathways.
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