Scott D. Ryan
University of Guelph
33 Papers
236 Citations
Scott D. Ryan is an academic researcher from University of Guelph. The author has contributed to research in topics: Biology & Dystonin. The author has an hindex of 19, co-authored 28 publications. Previous affiliations of Scott D. Ryan include University of Ottawa & Discovery Institute.
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Papers
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
TL;DR: In this article, a robust, patient-derived stem cell model of Parkinson's disease was used to identify mitochondrial toxin-induced perturbations in A53T α-synuclein (α-syn) mutant cells and isogenic mutation-corrected controls.
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Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
- 01 Dec 2013
TL;DR: Using a robust, patient-derived stem cell model of PD, the MEF2C-PGC1α pathway is identified as a therapeutic target to combat PD and mechanistic insight into gene-environmental interaction (GxE) in the pathogenesis of PD is provided.
342
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
Tammy Ryan,Vladimir V. Bamm,Morgan G. Stykel,Carla Coackley,Kayla M. Humphries,Rhiannon Jamieson-Williams,Rajesh Ambasudhan,Dick D. Mosser,Stuart A. Lipton,Stuart A. Lipton,George Harauz,Scott D. Ryan +11 more
TL;DR: It is demonstrated that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolIPin function can lead to spread of α- synuclein between neurons.
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
Shichun Tu,Mohd Waseem Akhtar,Rosa Maria Escorihuela,Rosa Maria Escorihuela,Alejandro Amador-Arjona,Vivek Swarup,James C. Parker,Jeffrey D. Zaremba,Timothy Holland,Neha Bansal,Daniel R. Holohan,Kevin M. Lopez,Scott D. Ryan,Scott D. Ryan,Shing Fai Chan,Li Yan,Xiaofei Zhang,Xiayu Huang,Abdullah Sultan,Scott R. McKercher,Scott R. McKercher,Rajesh Ambasudhan,Huaxi Xu,Yuqiang Wang,Daniel H. Geschwind,Amanda J. Roberts,Alexey V. Terskikh,Robert A. Rissman,Robert A. Rissman,Eliezer Masliah,Eliezer Masliah,Stuart A. Lipton,Nobuki Nakanishi +32 more
TL;DR: It is shown that Mef2c+/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can be ameliorated with the new drug, NitroSynapsin, a new dual-action compound related to the FDA-approved drug memantine.
Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative β-catenin
Karen Kennedy,Tammy Porter,Virja Mehta,Scott D. Ryan,Feodor D. Price,Vian Peshdary,Christina Karamboulas,Christina Karamboulas,Josée Savage,Thomas A. Drysdale,Shawn S.-C. Li,Steffany A. L. Bennett,Ilona S. Skerjanc,Ilona S. Skerjanc +13 more
TL;DR: RA can enhance skeletal myogenesis in stem cells at the muscle specification/progenitor stage by activating RARs bound directly to mesoderm and skeletal muscle progenitor genes, activating β-catenin function and inhibiting bone morphogenetic protein (BMP) signalling.