autoimmune diseases, for the treatment of cholangitis should be undertaken with caution. Interleukin 17 (IL-17) is assumed to be a driver of inflammation in several autoimmune diseases, such as psoriasis. IL-17 is also present in inflammatory diseases of the bile duct, but its role in these conditions is not clear, as the effects of IL-17 depend on the context of its expression. We here investigated the role of IL-17 in an experimental autoimmune cholangitis mouse model and we identified an important protective effect of IL-17 on cholangiocytes enabling them to downregulate bile duct inflammation via check point inhibitor PD-L1.

IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis via PD-1/PD-L1 interaction

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IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis via PD-1/PD-L1 interaction