Saumya Shah
University of Alberta
13 Papers
10 Citations
Saumya Shah is an academic researcher from University of Alberta. The author has contributed to research in topics: Medicine & Heart failure. The author has an hindex of 5, co-authored 7 publications.
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Papers
Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease
TL;DR: Targeting adipokines secreted from EAT and PVAT have a profound effect on the myocardium and coronary arteries; targeting these adipoksines could be an important therapeutic approach to counteract cardiovascular disease.
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Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Golam M. Uddin,Liyan Zhang,Saumya Shah,Arata Fukushima,Cory S. Wagg,Keshav Gopal,Rami Al Batran,Simran Pherwani,Kim L. Ho,Jamie Boisvenue,Qutuba G. Karwi,Qutuba G. Karwi,Tariq R. Altamimi,David S. Wishart,Jason R.B. Dyck,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +17 more
TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
Vaibhav B. Patel,Vaibhav B. Patel,Pavel Zhabyeyev,Xueyi Chen,Faqi Wang,Manish Paul,Dong Fan,Brent A. McLean,Ratnadeep Basu,Pu Zhang,Saumya Shah,John F. Dawson,W. Glen Pyle,Mousumi Hazra,Zamaneh Kassiri,Saugata Hazra,Bart Vanhaesebroeck,Christopher A. McCulloch,Gavin Y. Oudit +18 more
TL;DR: Gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium.
Shin-Haw Lee,Sina Hadipour-Lakmehsari,Da Hye Kim,Michelle Di Paola,Uros Kuzmanov,Saumya Shah,Joseph Lee,Thomas Kislinger,Parveen Sharma,Parveen Sharma,Gavin Y. Oudit,Anthony O. Gramolini +11 more
TL;DR: This comprehensive cardiomyocyte membrane proteome dataset will prove instrumental to future investigations aimed at characterizing heart disease markers and/or therapeutic targets for heart failure.
Novel Dominant–Negative Mutation in Cardiac Troponin I Causes Severe Restrictive Cardiomyopathy
Saumya Shah,Haran Yogasundaram,Ratnadeep Basu,Faqi Wang,David I. Paterson,Tero-Pekka Alastalo,Gavin Y. Oudit +6 more
TL;DR: A 30-year-old man with a known history of heart failure with preserved ejection fraction and paroxysmal atrial fibrillation diagnosed at 24 years of age was referred to the authors' service due to progressive heart failure.
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