Satoshi Ono
Mitsubishi Tanabe Pharma
19 Papers
166 Citations
Satoshi Ono is an academic researcher from Mitsubishi Tanabe Pharma. The author has contributed to research in topics: Energy landscape & Molecular dynamics. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Satoshi Ono include Tokyo Institute of Technology & Mitsubishi.
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Papers
Energy landscape of a peptide consisting of α-helix, 310-helix, β-turn, β-hairpin, and other disordered conformations
TL;DR: In this paper, a peptide was taken from the recognition helix of the DNA-binding protein, c-Myb, and a rugged energy landscape was obtained, in which the random-coil conformations were dominant at room temperature.
Peptide free-energy profile is strongly dependent on the force field: Comparison of C96 and AMBER95
TL;DR: The C96 and AMBER95 force fields were compared with small model peptides Ac-(Ala)n-NMe (Ac = CH3CO, NMe = NHCH3, n=2 and 3) in vacuo and in TIP3P water by computing the free energy profiles using multicanonical molecular dynamics method as discussed by the authors.
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Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.
Akihiro Furukawa,Joshua Schwochert,Cameron R. Pye,Daigo Asano,Quinn Edmondson,Alexandra C Turmon,Victoria G. Klein,Satoshi Ono,Okimasa Okada,R. Scott Lokey +9 more
TL;DR: This work generated two libraries of cyclic decapeptides with stable, cross- b conformations, and found that peptoid substitutions within the b -turns of the macrocycle preserved the rigidity of the parent scaffold, whereas peptoids in the opposing b -strands led to "chameleonic" species that were rigid in nonpolar media but highly flexible in water.
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Density Functional Study of the Radical Reactions of 3-Methyl-1-phenyl-2-pyrazolin-5-one (MCI-186): Implication for the Biological Function of MCI-186 as a Highly Potent Antioxidative Radical Scavenger
TL;DR: In this paper, a density functional method (B3LYP/6-31G*) with the self-consistent isodensity polarized continuum model (SCI-PCM) was used to investigate the radical reaction intermediates and products from the antioxidative radical scavenger MCI-186.
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Energy landscape of a β-hairpin peptide in explicit water studied by multicanonical molecular dynamics
TL;DR: In this article, a β-hairpin peptide in explicit water was studied with multicanonical molecular dynamics simulation, and the obtained energy landscape was separated into two regions: deep energy wells and rugged surface.
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