Satoshi Ohta
Jichi Medical University
26 Papers
104 Citations
Satoshi Ohta is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Biology & Gene knockdown. The author has an hindex of 12, co-authored 24 publications. Previous affiliations of Satoshi Ohta include Nara Institute of Science and Technology & The Research Institute at Nationwide Children's Hospital.
Chat about Author
Papers
PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA
Tetsuo Iida,Isao Suetake,Shoji Tajima,Hiroshi Morioka,Satoshi Ohta,Chikashi Obuse,Toshiki Tsurimoto +6 more
TL;DR: This work has shown that DNA cytosine methyltransferase 1 (Dnmt1), which preserves epigenetic signals by completing the methylation of hemimethylated DNA after DNA replication, is one of these PCNA binding proteins that interacts with a number of other proteins to increase their local concentration at replicated DNA sites.
142
The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle
TL;DR: The results indicate that ORC1 regulates the status of the ORC complex in human nuclei by tethering ORCs 2–5 to nuclear structures by formation of the OrC1–5 complex.
135
ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages
Akira Kawashima,Tadayoshi Karasawa,Kenji Tago,Hiroaki Kimura,Ryo Kamata,Fumitake Usui-Kawanishi,Sachiko Watanabe,Satoshi Ohta,Megumi Funakoshi-Tago,Ken Yanagisawa,Tadashi Kasahara,Koichi Suzuki,Masafumi Takahashi +12 more
TL;DR: This article identified an E3 ligase, Ariadne homolog 2 (ARIH2), as a posttranslational negative regulator of NLRP3 inflammasome activity in macrophages and highlights ARIH2 as a potential therapeutic target for inflammatory diseases.
The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.
TL;DR: Observations indicate that the ORC1 cycle in human cells is highly linked with cell cycle progression, allowing the initiation of replication to be coordinated with the cell cycle and preventing origins from refiring.
114
A Proteomics Approach to Identify Proliferating Cell Nuclear Antigen (PCNA)-binding Proteins in Human Cell Lysates IDENTIFICATION OF THE HUMAN CHL12/RFCs2–5 COMPLEX AS A NOVEL PCNA-BINDING PROTEIN
TL;DR: In this paper, the authors carried out systematic studies of PCNA-binding proteins by a combination of affinity chromatography and mass spectrometric analyses and detected more than 20 specific protein bands of various intensities in fractions bound to PCNA fixed resin from human cell lysates and determined their peptide sequences by liquid chromatography.
92