Saskia Villinger
Max Planck Society
7 Papers
64 Citations
Saskia Villinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Voltage-dependent anion channel & Voltage-Dependent Anion Channel 1. The author has an hindex of 6, co-authored 7 publications.
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Papers
Structure of the human voltage-dependent anion channel
Monika Bayrhuber,Thomas Meins,Michael Habeck,Stefan Becker,Karin Giller,Saskia Villinger,Clemens Vonrhein,Christian Griesinger,Markus Zweckstetter,Kornelius Zeth +9 more
TL;DR: The 3D structure of human VDAC1 was solved conjointly by NMR spectroscopy and x-ray crystallography in this paper, which is the most abundant protein in the mitochondrial outer membrane (MOM).
Functional dynamics in the voltage-dependent anion channel
Saskia Villinger,Rodolfo Briones,Karin Giller,Ulrich Zachariae,Adam Lange,Bert L. de Groot,Christian Griesinger,Stefan Becker,Markus Zweckstetter +8 more
TL;DR: In this paper, a combination of solution NMR spectroscopy, Gaussian network model analysis, and molecular dynamics simulation was used to reveal functional dynamics of isoform one of VDAC (VDAC1) by a combination.
Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane.
Lin Ge,Saskia Villinger,Stefania A. Mari,Karin Giller,Christian Griesinger,Stefan Becker,Daniel J. Müller,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter +9 more
TL;DR: It is shown that the β barrel of human VDAC embedded into a membrane is highly flexible and its mechanical flexibility exceeds by up to one order of magnitude that determined for β strands of other membrane proteins.
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Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1.
Rodolfo Briones,Conrad Weichbrodt,Licia Paltrinieri,Ingo Mey,Saskia Villinger,Karin Giller,Adam Lange,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Christian Griesinger,Stefan Becker,Claudia Steinem,Bert L. de Groot +13 more
TL;DR: The submicrosecond VDAC-1 voltage response shows intrinsic structural changes that explain the role of key gating amino acids and support some of the current gating hypotheses, including asymmetric barrel distortion, its interaction with the membrane, and significant displacement of N-α amino acids.
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Nucleotide interactions of the human voltage-dependent anion channel.
Saskia Villinger,Karin Giller,Monika Bayrhuber,Adam Lange,Christian Griesinger,Stefan Becker,Markus Zweckstetter +6 more
TL;DR: In this article, the binding of nucleotides to human VDAC1 (hVDAC1) on a single-residue level using NMR spectroscopy and site-directed mutagenesis was characterized.
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