Saskia Schulthoff
Max Planck Society
9 Papers
117 Citations
Saskia Schulthoff is an academic researcher from Max Planck Society. The author has contributed to research in topics: Total synthesis & Alkyne metathesis. The author has an hindex of 8, co-authored 9 publications.
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Papers
Total Synthesis and Biological Evaluation of the Cytotoxic Resin Glycosides Ipomoeassin A–F and Analogues
Takashi Nagano,Jiří Pospíšil,Guillaume Chollet,Saskia Schulthoff,Volker Hickmann,Emilie Moulin,Jennifer Herrmann,Rolf Müller,Alois Fürstner +8 more
TL;DR: A multitasking C-silylation strategy using the readily available compound 26 as a surrogate for cinnamic acid represents the key design element of a total synthesis of all known members of the ipomoeassin family of resin glyosides as discussed by the authors.
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•Journal Article
Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A–F and analogues
Takashi Nagano,Jiří Pospíšil,Guillaume Chollet,Saskia Schulthoff,Volker Hickmann,Emilie Moulin,Jennifer Herrmann,Rolf Müller,Alois Fürstner +8 more
TL;DR: A multitasking C-silylation strategy using the readily available compound 26 as a surrogate for cinnamic acid represents the key design element of a total synthesis of all known members of the ipomoeassin family of resin glyosides.
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Total Synthesis of Berkelic Acid
Thomas N. Snaddon,Philipp Buchgraber,Saskia Schulthoff,Cornelia Wirtz,Richard Mynott,Alois Fürstner +5 more
TL;DR: A productive total synthesis of both enantiomers of berkelic acid is outlined that takes the structure revision of this bioactive fungal metabolite previously proposed by the group into account, which clearly surpasses the classical Ireland-Claisen procedure in terms of diastereoselectivity.
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A Total Synthesis of Spirastrellolide A Methyl Ester
TL;DR: Preliminary biological data suggest that the entire carbon framework, that is the macrocyclic core plus the lateral chain, might be necessary for high cytotoxicity.
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The Formosalides: Structure Determination by Total Synthesis
TL;DR: Total synthesis allowed the constitution of the cytotoxic marine macrolides of the formosalide family to be confirmed and their previously unknown stereostructure to be assigned with confidence.
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