Saskia Maas
Leiden University Medical Center
18 Papers
29 Citations
Saskia Maas is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Biology & Heart development. The author has an hindex of 12, co-authored 17 publications.
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Papers
Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.
Heleen Lie-Venema,Nynke M. S. van den Akker,Noortje A.M. Bax,Elizabeth M. Winter,Saskia Maas,Tuija Kekarainen,Rob C. Hoeben,Marco C. DeRuiter,Robert E. Poelmann,Adriana C. Gittenberger-de Groot +9 more
TL;DR: A role for EPDCs in cardiac looping is proposed, and their contribution to the development of the valves and myocardial architecture is emphasized, and congenital heart anomalies that might be caused primarily by an epicardial developmental defect are focused on.
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PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation.
Nynke M.S. Van Den Akker,Leah C.J. Winkel,Maya H. Nisancioglu,Saskia Maas,Lambertus J. Wisse,Annika Armulik,Robert E. Poelmann,Heleen Lie-Venema,Christer Betsholtz,Adriana C. Gittenberger-de Groot +9 more
TL;DR: The observed abnormalities correspond with models in which epicardial development is impaired and with neuronal neural crest–related innervation deficits, which implies a role for PDGF‐B/PDGFR‐β‐signaling specifically in the contribution of these cell lineages to cardiac development.
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Epicardium-derived cells enhance proliferation, cellular maturation and alignment of cardiomyocytes
Alida H. Weeke-Klimp,Noortje A.M. Bax,Anna Rita Bellu,Elizabeth M. Winter,Johannes Vrolijk,Josee A. Plantinga,Saskia Maas,Marja G. L. Brinker,Edris A.F. Mahtab,Adriana C. Gittenberger-de Groot,Marja J. A. van Luyn,Martin C. Harmsen,Heleen Lie-Venema +12 more
TL;DR: It is implicate that EPDCs are ideal candidates as adjuvant cells for cardiomyocyte integration during cardiac (stem) cell therapy, as well as the expression and cellular distribution of proteins involved in myocardial maturation.
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In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1
Nam Noortje Bax,Angelique A M Van Oorschot,Saskia Maas,Jerry Braun,John van Tuyn,Antoine A.F. de Vries,Adriana C. Gittenberger-de Groot,Marie-José Goumans +7 more
TL;DR: It is shown that TGFβ-induced EMT is dependent on type-1 TGF β receptor activity and can be inhibited by soluble VCAM-1, and epicardial-specific knockdown of Wilms tumor-1 (WT1) induces the process of EMT in human adult epicardials cells, through transcriptional regulation of platelet-derived growth factor receptor alpha (Pdgfrα), Snai1 and VCAM1.
Platelet-derived growth factors in the developing avian heart and maturating coronary vasculature.
Nynke M.S. Van Den Akker,Heleen Lie-Venema,Saskia Maas,Ismail Eralp,Marco C. DeRuiter,Robert E. Poelmann,Adriana C. Gittenberger-de Groot +6 more
TL;DR: It is concluded that all four proteins are involved in myocardial development, whereas PDGF‐B and PDGFR‐β are specifically important in coronary maturation.
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