Saskia L. Smits
Erasmus University Rotterdam
78 Papers
259 Citations
Saskia L. Smits is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 33, co-authored 75 publications.
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Papers
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
V. Stalin Raj,Huihui Mou,Saskia L. Smits,Dick H. W. Dekkers,Marcel A. Müller,Ronald Dijkman,Doreen Muth,Jeroen Demmers,Ali Moh Zaki,Ron A. M. Fouchier,Volker Thiel,Volker Thiel,Christian Drosten,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Berend Jan Bosch,Bart L. Haagmans +16 more
TL;DR: Dipeptidyl peptidase 4 (DPP4; also known as CD26) is identified as a functional receptor for hCoV-EMC and will contribute critically to the understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
Chantal B.E.M. Reusken,Bart L. Haagmans,Marcel A. Müller,Carlos Gutierrez,Gert Jan Godeke,Benjamin Meyer,Doreen Muth,V. Stalin Raj,Laura Smits De Vries,Victor M. Corman,Jan Felix Drexler,Saskia L. Smits,Yasmin El Tahir,Rita de Sousa,Janko van Beek,Norbert Nowotny,Norbert Nowotny,Kees van Maanen,Ezequiel Hidalgo-Hermoso,Berend Jan Bosch,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Christian Gortázar-Schmidt,Christian Drosten,Marion Koopmans +24 more
TL;DR: Both titres and seroprevalences in sera from different locations in Oman suggest widespread infection of camel populations, and possible animal reservoirs of MERS-CoV are investigated by assessing specific serum antibodies in livestock.
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Virus genomes reveal factors that spread and sustained the Ebola epidemic
Gytis Dudas,Gytis Dudas,Luiz Max Carvalho,Trevor Bedford,Andrew J. Tatem,Guy Baele,Nuno R. Faria,Daniel J. Park,Jason T. Ladner,Armando Arias,Armando Arias,Danny Asogun,Filip Bielejec,Sarah L Caddy,Matthew Cotten,Matthew Cotten,Jonathan D'ambrozio,Simon Dellicour,Antonino Di Caro,Joseph W. Diclaro,Sophie Duraffour,Michael J. Elmore,Lawrence Fakoli,Ousmane Faye,Merle L. Gilbert,Sahr M. Gevao,Stephen K. Gire,Stephen K. Gire,Adrianne Gladden-Young,Andreas Gnirke,Augustine Goba,Donald S. Grant,Bart L. Haagmans,Julian A. Hiscox,Umaru Jah,Jeffrey R. Kugelman,Di Liu,Jia Lu,Christine M. Malboeuf,Suzanne Mate,David A. Matthews,Christian B. Matranga,Luke W. Meredith,Luke W. Meredith,James Qu,Joshua Quick,Susan D. Pas,My V. T. Phan,My V. T. Phan,Georgios Pollakis,Chantal B.E.M. Reusken,Mariano Sanchez-Lockhart,Stephen F. Schaffner,John S. Schieffelin,Rachel Sealfon,Rachel Sealfon,Etienne Simon-Loriere,Etienne Simon-Loriere,Saskia L. Smits,Kilian Stoecker,Lucy Thorne,Ekaete Alice Tobin,Mohamed A. Vandi,Simon J. Watson,Kendra West,Shannon L.M. Whitmer,Michael R. Wiley,Sarah M. Winnicki,Sarah M. Winnicki,Shirlee Wohl,Shirlee Wohl,Roman Wölfel,Nathan L. Yozwiak,Nathan L. Yozwiak,Kristian G. Andersen,Kristian G. Andersen,Sylvia O. Blyden,Fatorma K. Bolay,Miles W. Carroll,Bernice Dahn,Boubacar Diallo,Pierre Formenty,Christophe Fraser,George F. Gao,Robert F. Garry,Ian Goodfellow,Ian Goodfellow,Stephan Günther,Christian T. Happi,Edward C. Holmes,Brima Kargbo,Sakoba Keita,Paul Kellam,Paul Kellam,Marion Koopmans,Jens H. Kuhn,Nicholas J. Loman,N’Faly Magassouba,Dhamari Naidoo,Stuart T. Nichol,Tolbert Nyenswah,Gustavo Palacios,Oliver G. Pybus,Pardis C. Sabeti,Pardis C. Sabeti,Amadou A. Sall,Ute Ströher,Isatta Wurie,Marc A. Suchard,Philippe Lemey,Andrew Rambaut +110 more
TL;DR: It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics.
An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
Bart L. Haagmans,Judith M. A. van den Brand,V. Stalin Raj,Asisa Volz,Peter Wohlsein,Saskia L. Smits,Debby Schipper,Theo M. Bestebroer,Nisreen M.A. Okba,Robert Fux,Albert Bensaid,David Solanes Foz,Thijs Kuiken,Wolfgang Baumgärtner,Joaquim Segalés,Gerd Sutter,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus +18 more
TL;DR: It is shown that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels, and that induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.
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Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines.
Marcel A. Müller,V. Stalin Raj,Doreen Muth,Benjamin Meyer,Stephan Kallies,Saskia L. Smits,Robert Wollny,Theo M. Bestebroer,Sabine Specht,Tasnim Suliman,Katrin Zimmermann,Tabea Binger,Isabella Eckerle,Marco Tschapka,Ali Moh Zaki,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Bart L. Haagmans,Christian Drosten +18 more
TL;DR: Results show that hCoV-EMC does not need the SARS-CoV receptor to infect human cells, implicating a low barrier against cross-host transmission.
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