Saša Šviković
Laboratory of Molecular Biology
19 Papers
15 Citations
Saša Šviković is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: DNA replication & Biology. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Saša Šviković include University of Belgrade.
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Papers
Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
M. Peterka,Nina Akrap,Songyuan Li,Sandra Wimberger,Pei Pei Hsieh,D I Degtev,Burcu Bestas,Jack Barr,Stijn van de Plassche,Patricia Mendoza-Garcia,Saša Šviković,Grzegorz Sienski,Mike Firth,Marcello Maresca +13 more
TL;DR: In this paper , the authors exploit DNA double-strand break (DSB) repair to develop two strategies that install precise genomic insertions using an SpCas9 nuclease-based prime editor (PEn).
Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
Sandra Wimberger,Nina Akrap,Mike Firth,Johan Brengdahl,Susanna Engberg,Marie K. Schwinn,Michael R. Slater,Anders Lundin,Pei Pei Hsieh,Songyuan Li,Silvia Cerboni,Jonathan Sumner,Burcu Bestas,Bastian Schiffthaler,Björn Magnusson,Silvio Di Castro,Preeti Iyer,Bohlooly-Y Mohammad,Thomas Machleidt,Steve Rees,Ola Engkvist,T P Norris,Elaine Cadogan,Josep V. Forment,Saša Šviković,Pinar Akcakaya,Amir Taheri-Ghahfarokhi,Marcello Maresca +27 more
TL;DR: Zhang et al. as discussed by the authors proposed a DNA-dependent protein kinase (DNA-PK) inhibitor and potent enhancer of CRISPR-Cas9-mediated integration.
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Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
Martin Peterka,Nina Akrap,Songyuan Li,Sandra Wimberger,Pei-Pei Hsieh,Dmitrii Degtev,Burcu Bestas,Jack Barr,Stijn van de Plassche,Patricia Mendoza-Garcia,Saša Šviković,Grzegorz Sienski,Mike Firth,Marcello Maresca +13 more
TL;DR: In this article, the authors exploit DNA double-strand break (DSB) repair to develop two novel strategies that install precise genomic insertions using an SpCas9 nuclease-based prime editor.
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The intersection of DNA replication with antisense 3' RNA processing in Arabidopsis FLC chromatin silencing.
TL;DR: The authors showed that RNA 3' processing factors (FCA and FY) are required for unimpeded replication fork progression across the Arabidopsis genome across the chicken DT40 cell line system, using single-molecule DNA fiber analysis.
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Genetic testing of individuals with pre‐senile cataract identifies patients with myotonic dystrophy type 2
Vidosava Rakocevic-Stojanovic,Stojan Peric,Jovan Pesovic,I. Senćanić,M. Božić,Saša Šviković,Miloš Brkušanin,Dusanka Savic-Pavicevic +7 more
TL;DR: This research attacked the mode of action of central giant cell apoptosis by targeting the Tournaisian nervous system, which is known as “cell reprograming” and has a significant role in the development of Alzheimer's disease.
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