Sarika Saraswati
Vanderbilt University Medical Center
22 Papers
57 Citations
Sarika Saraswati is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Mesenchymal stem cell & Wnt signaling pathway. The author has an hindex of 13, co-authored 21 publications. Previous affiliations of Sarika Saraswati include Vanderbilt University & University of Arkansas for Medical Sciences.
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Papers
Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.
Sarika Saraswati,Maria P. Alfaro,Curtis A. Thorne,James B. Atkinson,James B. Atkinson,Ethan Lee,Pampee P. Young,Pampee P. Young +7 more
TL;DR: Pyrvinium reduced adverse cardiac remodeling demonstrated by decreased left ventricular internal diameter in diastole (LVIDD) as compared to a control compound, and increased Ki-67+ cells were observed in peri-infarct and distal myocardium of pyrvinia-treated animals.
Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing.
TL;DR: The identification of FSP1-GFP+ cells as a non-pericyte, non-hematopoietic fibroblast subpopulation with a predominant pro-angiogenic role is reported, characterized by in vitro phenotypic/cellular/ultrastructural studies and in vivo granulation tissue formation assays combined with transcriptomics and proteomics.
Galectin-3 is associated with prostasomes in human semen
Jennifer L. Jones,Sarika Saraswati,Ashley S. Block,Cheryl F. Lichti,Cheryl F. Lichti,Maha M. Mahadevan,Alan B. Diekman +6 more
TL;DR: The formation of a monovalent galectin-3 fragment with conserved carbohydrate-binding activity indicates the functional relevance of this truncation and suggests a regulatory mechanism for galectIn-3 in prostasomes, which lays the groundwork for future studies of galectine-3 and prostasome in reproduction, disease transmission, and cancer progression.
Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury
Dikshya Bastakoty,Sarika Saraswati,Justin M M Cates,Ethan Lee,Lillian B. Nanney,Pampee P. Young +5 more
TL;DR: The study shows that pharmacologic Wnt inhibition holds therapeutic utility for regenerative repair of cutaneous wounds and that topical application of small‐molecule Wnt inhibitors can reduce fibrosis and promote regenerative cutaneous wound repair.
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Co‐purification of Mac‐2 binding protein with galectin‐3 and association with prostasomes in human semen
Ashley S. Block,Sarika Saraswati,Sarika Saraswati,Cheryl F. Lichti,Cheryl F. Lichti,Maha M. Mahadevan,Alan B. Diekman +6 more
TL;DR: Functional characterization of galectin‐3 in a given biological environment includes identification of its target glycoprotein ligands and the role they play in regulation of sperm function, immunosuppression, and prostate cancer progression.
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