Sarah Wright
Sunesis Pharmaceuticals
23 Papers
500 Citations
Sarah Wright is an academic researcher from Sunesis Pharmaceuticals. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 14, co-authored 23 publications.
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Papers
The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates
H. Michael Tucker,Muthoni Kihiko,Joseph N. Caldwell,Sarah Wright,Takeshi Kawarabayashi,Douglas A. Price,Donald Walker,Stephen W. Scheff,Joseph P. McGillis,Russell E. Rydel,Steven Estus +10 more
TL;DR: Results are interpreted as consistent with the possibility that the plasmin pathway is induced by aggregated Aβ, which can lead to Aβ degradation and inhibition of Aβ actions.
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A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.
Matthew F. Burkhardt,Fernando J. Martinez,Sarah Wright,Carla Ramos,Dmitri Volfson,Michael Mason,Jeff Garnes,Vu Dang,Jeffery Lievers,Uzma Shoukat-Mumtaz,Rita Martinez,Hui Gai,Robert Blake,Eugeni A. Vaisberg,Marica Grskovic,Charles Johnson,Stefan Irion,Bright Jessica Michelle,Bonnie Cooper,Leane Nguyen,Irene Griswold-Prenner,Ashkan Javaherian +21 more
TL;DR: It is demonstrated that motor neurons derived from three sALS patients show de novo TDP-43 aggregation and that the aggregates recapitulate pathology in postmortem tissue from one of the same patients from which the iPSC were derived.
309
Aggregated Amyloid-Beta Protein Induces Cortical Neuronal Apoptosis and Concomitant "Apoptotic" Pattern of Gene Induction
Steven Estus,H. Michael Tucker,Corlia van Rooyen,Sarah Wright,Elizabeth F. Brigham,Mark Wogulis,Russell E. Rydel +6 more
TL;DR: The overall gene expression pattern during this “physiologically inappropriate” apoptotic stimulus is markedly similar to the pattern the authors previously identified after a “ Physiologically appropriate” stimulus, Hence, the parallels identified here further the understanding of the genetic alterations that may lead neurons to apoptosis in response to markedly different insults.
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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
Kelly J. Inglis,David Chereau,Elizabeth F. Brigham,San-San Chiou,Susanne Schöbel,Normand Frigon,Mei Yu,Russell J. Caccavello,Seth Nelson,Ruth Motter,Sarah Wright,David Chian,Pamela Santiago,Ferdie Soriano,Carla Ramos,Kyle Powell,Jason Goldstein,Michael Babcock,Ted Yednock,Frederique Bard,Guriqbal S. Basi,Hing Sham,Tamie J. Chilcote,Lisa McConlogue,Irene Griswold-Prenner,John P. Anderson +25 more
TL;DR: Evidence is submitted that polo-like kinase 2 (PLK2), also known as serum-inducible kinase or SNK, is a principle contributor to α-synuclein phosphorylation at Ser-129 in neurons in neurons.
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Amyloid β‐Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H2O2 Generation
Zhiyuan Zhang,Russell E. Rydel,Gary J. Drzewiecki,Kimberly S. Fuson,Sarah Wright,Mark Wogulis,James E. Audia,Patrick C. May,Paul A. Hyslop +8 more
TL;DR: It is demonstrated that intracellular ATP concentration is compromised during the first 24‐h exposure of neurons to Aβ, and it is suggested that impairment of energy homeostasis may be a more significant early factor in the neurodegenerative process.
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