5 Papers
104 Citations
Sarah Odeh is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Farnesyl diphosphate synthase & Trypanosoma brucei. The author has an hindex of 4, co-authored 5 publications.
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Papers
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Yan Ling,Gurmukh Sahota,Sarah Odeh,Julian M. W. Chan,Fausto G. Araujo,Silvia N.J. Moreno,Silvia N.J. Moreno,Eric Oldfield +7 more
TL;DR: The three most active compounds found in vitro were tested in vivo in a Smith-Webster mouse model and the two most active bisphosphonates were found to provide up to an 80% protection from death, a considerable improvement over that found previously with nitrogen-containing bisph phosphate compounds.
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Inhibition of Trypanosoma cruzi Hexokinase by Bisphosphonates
Michael P. Hudock,Carlos E. Sanz-Rodriguez,Yongcheng Song,Julian M. W. Chan,Yonghui Zhang,Sarah Odeh,Thomas Kosztowski,Annette Leon-Rossell,J L Concepción,Vanessa Yardley,Simon L. Croft,Julio A. Urbina,Eric Oldfield +12 more
TL;DR: It is shown that non-hydrolyzable analogues of PPi, bisphosphonates, are potent inhibitors of T. cruzi hexokinase, the first enzyme involved in glycolysis in most organisms.
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Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
John M. Sanders,Yongcheng Song,Julian M. W. Chan,Yonghui Zhang,Samuel Jennings,Thomas Kosztowski,Sarah Odeh,Ryan M. Flessner,Christine A. Schwerdtfeger,Evangelia Kotsikorou,Gary A. Meints,Aurora Ortiz Gomez,Dolores González-Pacanowska,Amy M. Raker,Hong Wang,Ermond van Beek,Socrates E. Papapoulos,Craig T. Morita,Eric Oldfield +18 more
TL;DR: The most potent molecules have high activity against an expressed FPPS from Leishmania major, in Dictyostelium discoideum growth inhibition, in gammadelta T cell activation and in an in vitro bone resorption assay.
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Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei.
Junhong Mao,Yi Gui Gao,Sarah Odeh,Howard Robinson,Andrea Montalvetti,Roberto Docampo,Eric Oldfield +6 more
TL;DR: An initial model of the drug-free protein has been built using a homology model with the molecular-replacement method and shows mostly helical structure and resembles the structure of avian farnesyl diphosphate synthase, but with the addition of two loop regions.
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