Sarah Nicklas
University of Luxembourg
8 Papers
Sarah Nicklas is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Neural stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Sarah Nicklas include University of Münster.
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Papers
Modeling Parkinson’s disease in midbrain-like organoids
Lisa M. Smits,Lydia Reinhardt,Lydia Reinhardt,Peter Reinhardt,Peter Reinhardt,Michael Glatza,Michael Glatza,Anna S. Monzel,Nancy Stanslowsky,Marcelo D. Rosato-Siri,Alessandra Zanon,Paul Antony,Jessica Bellmann,Sarah Nicklas,Kathrin Hemmer,Xiaobing Qing,Emanuel Berger,Norman Kalmbach,Marc Ehrlich,Silvia Bolognin,Andrew A. Hicks,Florian Wegner,Jared Sterneckert,Jared Sterneckert,Jens Christian Schwamborn +24 more
TL;DR: It is demonstrated that three-dimensional differentiation of expandable midbrain floor plate neural progenitor cells (mfNPCs) leads to organoids that resemble key features of the human midbrain that investigate PD-relevant patho-mechanisms.
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.
Sarah Nicklas,Sarah Nicklas,Anna-Lena Hillje,Anna-Lena Hillje,Satoshi Okawa,Ina-Maria Rudolph,Franziska Melanie Collmann,Thea van Wuellen,Thea van Wuellen,Antonio del Sol,Jens Christian Schwamborn,Jens Christian Schwamborn +11 more
TL;DR: It is shown that TRIM32 associates with the deubiquitination enzyme USP7, which previously has been implicated in neural stem cell maintenance, and that this function is required to maintain Neural stem cell fate.
The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells
Lamia A Bahnassawy,Sarah Nicklas,Thomas Palm,Ingeborg Menzl,Fabian Birzele,Frank Gillardon,Jens Christian Schwamborn +6 more
TL;DR: It is indicated that LRRK2 regulates the level of cellular oxidative stress and thereby influences the survival of NSCs and leads to an up-regulation of neuronal differentiation-inducing processes, including the Let-7a pathway.
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Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32
TL;DR: It is demonstrated that the miRNA activity inhibition function of pathogenic LRRK2 is directly antagonized by the neuronal cell fate determinant TRIM 32, suggesting that TRIM32 might be a modifier for PD and could be a novel therapeutic target.
A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers
TL;DR: A GRN-based model of stem cell differentiation and a computational method that can systematically predict cell-fate determinants and their GRN motifs can guide differentiation experiments in stem cell research and regenerative medicine.