Sarah M. Mense
Columbia University
20 Papers
54 Citations
Sarah M. Mense is an academic researcher from Columbia University. The author has contributed to research in topics: PTEN & Tensin. The author has an hindex of 17, co-authored 20 publications. Previous affiliations of Sarah M. Mense include Icahn School of Medicine at Mount Sinai.
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Papers
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Benjamin D. Hopkins,Barry Fine,Nicole Steinbach,Nicole Steinbach,Meaghan Dendy,Zachary Rapp,Jacquelyn Shaw,Jacquelyn Shaw,Kyrie Pappas,Kyrie Pappas,Jennifer S. Yu,Cindy Hodakoski,Sarah M. Mense,Joshua U. Klein,Joshua U. Klein,Sarah Pegno,Maria Luisa Sulis,Maria Luisa Sulis,Hannah E. Goldstein,Hannah E. Goldstein,Benjamin Amendolara,Benjamin Amendolara,Liang Lei,Liang Lei,Matthew Maurer,Matthew Maurer,Jeffrey N. Bruce,Peter Canoll,Peter Canoll,Hanina Hibshoosh,Hanina Hibshoosh,Ramon Parsons +31 more
TL;DR: A 576–amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence, adding 173 N-terminal amino acids to the normal PTEN open reading frame may have therapeutic uses.
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases.
Sarah M. Mense,Li Zhang +1 more
TL;DR: The current knowledge about how heme controls the activity of transcriptional regulators and signal transducers is summarized, and diseases associated with defective heme synthesis, degradation and function are discussed.
PTEN function, the long and the short of it
TL;DR: This review focuses on modes of PTEN protein regulation and ways in which perturbations in this regulation may lead to disease.
295
Phytoestrogens and breast cancer prevention: possible mechanisms of action.
TL;DR: It is suggested that despite numerous investigations, the mechanisms of phytoestrogen action in breast cancer have yet to be elucidated and it remains uncertain whether these plant compounds are chemoprotective or whether they may produce adverse outcomes related to breast carcinogenesis.
236
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes.
Sarah M. Mense,Amitabha Sengupta,Mei Zhou,Changgui Lan,Galina Bentsman,David J. Volsky,Li Zhang +6 more
TL;DR: A global view of the signaling and regulatory network mediating oxygen regulation in human astrocytes is provided and many target genes of the EGF and insulin signaling pathways and the transcriptional regulators Myc, Jun, and p53 were selectively altered by hypoxia in astroCytes.
129