Sarah Lück
Humboldt University of Berlin
5 Papers
Sarah Lück is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Sarah Lück include Charité.
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Papers
Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver
Jingkui Wang,Laura Symul,Jake Yeung,Cédric Gobet,Cédric Gobet,Jonathan Sobel,Sarah Lück,Pål O. Westermark,Nacho Molina,Felix Naef +9 more
TL;DR: A mathematical model based on total RNA-seq was developed to classify genes according to the respective contributions of transcriptional and posttranscriptional regulation toward mRNA expression profiles, and it was found that about one-third of rhythmically accumulating mRNA are under posttranscriptal regulation.
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Circadian mRNA expression: insights from modeling and transcriptomics
Sarah Lück,Pål O. Westermark +1 more
TL;DR: The charting of circadian output rhythms in mRNA expression, focusing on mammals, is reviewed, emphasizing the challenges in statistics, interpretation, and quantitative descriptions that such investigations have faced and continue to face, and outline remaining outstanding questions.
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Origin of Cardiac Troponin T Elevations in Chronic Kidney Disease.
Noreen van der Linden,Tom Cornelis,Dorien M Kimenai,Lieke J.J. Klinkenberg,Judith M Hilderink,Sarah Lück,Elisabeth J R Litjens,Frederique E C M Peeters,Alexander S. Streng,Tobias Breidthardt,Luc J. C. van Loon,Otto Bekers,Jeroen P. Kooman,Pål O. Westermark,Christian Mueller,Steven J.R. Meex +15 more
TL;DR: The recently demonstrated rhythmic diurnal oscillation pattern of troponin T is used as a model to assess the contribution of impaired renal elimination to persistently elevated cardiac Troponin levels in patients with CKD.
Insulin Directly Regulates the Circadian Clock in Adipose Tissue.
Neta Tuvia,Olga Pivovarova-Ramich,Veronica Murahovschi,Sarah Lück,Astrid Grudziecki,Anne-Catrin Ost,Michael Kruse,Victoria J. Nikiforova,Martin Osterhoff,Pascal Gottmann,Özlem Gögebakan,Carsten Sticht,Norbert Gretz,Michael Schupp,Annette Schürmann,Natalia Rudovich,Andreas Pfeiffer,Achim Kramer +17 more
TL;DR: This article showed that post-prandial changes of the hormone insulin directly entrain circadian clocks in AT and investigated a transcriptional-dependent mechanism of this regulation, showing that feeding is a "zeitgeber" aligning the clock in AT with the external time.
Rhythmic degradation explains and unifies circadian transcriptome and proteome data.
TL;DR: A theoretical framework is derived that fully describes the amplitudes and phases of biomolecules with circadian half-lives and estimates that 30% of the circadian transcripts in mouse liver and Drosophila heads are affected by rhythmic posttranscriptional regulation.