Sarah E. Huff
Case Western Reserve University
4 Papers
27 Citations
Sarah E. Huff is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Ribonucleotide reductase & Viral replication. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Sarah E. Huff include Florida State University College of Arts and Sciences.
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Papers
Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors.
Sarah E. Huff,Indrasena Reddy Kummetha,Shashi Kant Tiwari,Matthew B. Huante,Alex E. Clark,Shaobo Wang,William Bray,Davey M. Smith,Aaron F. Carlin,Mark A. Endsley,Tariq M. Rana +10 more
TL;DR: Wang et al. as mentioned in this paper identified a 2-phenyl-1,2-benzoselenazol-3-one class of compounds targeting the SARS-CoV-2 main protease (Mpro).
Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
Md. Faiz Ahmad,Sarah E. Huff,John J. Pink,Intekhab Alam,Andrew Zhang,Kay Perry,Michael E. Harris,Tessianna A. Misko,Suheel K. Porwal,Nancy L. Oleinick,Masaru Miyagi,Rajesh Viswanathan,Chris Dealwis +12 more
TL;DR: Using virtual screening, binding affinity, inhibition, and cell toxicity, a class of small molecules are discovered that alter the equilibrium of inactive hexamers of RR, leading to its inhibition.
Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase
Sarah E. Huff,Faiz Ahmad Mohammed,Mu Yang,Prashansa Agrawal,John J. Pink,Michael E. Harris,Chris Dealwis,Rajesh Viswanathan +7 more
TL;DR: The synthesis and biochemical characterization of 25 distinct analogs of human RR are reported, providing a novel way of inhibition of this crucial enzyme through a reversible and competitive mode.
Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Faiz Ahmad,Intekhab Alam,Sarah E. Huff,John J. Pink,Sheryl A. Flanagan,Donna S. Shewach,Tessianna A. Misko,Nancy L. Oleinick,William E. Harte,Rajesh Viswanathan,Michael E. Harris,Chris Dealwis +11 more
TL;DR: The identification and characterization of a unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), is reported, using virtual screening, binding affinity, inhibition, and cell toxicity assays to provide evidence for RR inhibition in cells.