Sarah Devriese
Ghent University
12 Papers
9 Citations
Sarah Devriese is an academic researcher from Ghent University. The author has contributed to research in topics: Inflammatory bowel disease & Ursodeoxycholic acid. The author has an hindex of 6, co-authored 12 publications.
Chat about Author
Papers
Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
Annelies Geirnaert,Annelies Geirnaert,Marta Calatayud,Charlotte Grootaert,Debby Laukens,Sarah Devriese,Guy Smagghe,Martine De Vos,Nico Boon,Tom Van de Wiele +9 more
TL;DR: Proof-of-concept data for the therapeutic potential of butyrate-producing bacteria in CD is provided and the future preclinical development of a probiotic product containing butyrATE-producing species is supported.
384
Reduced Mucosa-associated Butyricicoccus Activity in Patients with Ulcerative Colitis Correlates with Aberrant Claudin-1 Expression.
Sarah Devriese,Venessa Eeckhaut,Annelies Geirnaert,Lien Van den Bossche,Pieter Hindryckx,Tom Van de Wiele,Filip Van Immerseel,Richard Ducatelle,Martine De Vos,Debby Laukens +9 more
TL;DR: Butyricicoccus is a mucosa-associated bacterial genus under-represented in colonic mucosa of patients with active UC, whose activity inversely correlates with CLDN1 expression, supporting its use as a pharmabiotic preserving epithelial TJ integrity.
149
Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice
Lien Van den Bossche,Pieter Hindryckx,Lindsey Devisscher,Sarah Devriese,Sophie Van Welden,Tom Holvoet,Ramiro Vilchez-Vargas,Marius Vital,Dietmar H. Pieper,Julie Vanden Bussche,Lynn Vanhaecke,Tom Van de Wiele,Martine De Vos,Debby Laukens +13 more
TL;DR: Results show that secondary bile acids reduce the severity of colitis and ameliorate colitis-associated fecal dysbiosis at the phylum level and conclude that UDCA, which is an FDA-approved drug for cholestatic liver disorders, could be an attractive treatment option to reduce Dysbiosis and amaliorate inflammation in human IBD.
126
T84 monolayers are superior to Caco-2 as a model system of colonocytes.
Sarah Devriese,Lien Van den Bossche,Sophie Van Welden,Tom Holvoet,Iris Pinheiro,Pieter Hindryckx,Martine De Vos,Debby Laukens +7 more
TL;DR: In this article, the authors compared Caco-2 and T84 epithelial cells and found that T84 cells exhibited a dose-responsive improvement of barrier function towards butyrate.
82
Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.
Sophie Van Welden,Martine De Vos,Ben Wielockx,Simon Tavernier,Melissa Dullaers,Sara Neyt,Benedicte Descamps,Lindsey Devisscher,Sarah Devriese,Lien Van den Bossche,Tom Holvoet,Ann Baeyens,Carmen Correale,Silvia D'Alessio,Christian Vanhove,Filip De Vos,Bruno Verhasselt,Georg Breier,Bart N. Lambrecht,Sophie Janssens,Peter Carmeliet,Silvio Danese,Dirk Elewaut,Debby Laukens,Pieter Hindryckx +24 more
TL;DR: It is demonstrated that Phd1 deletion in endothelial and haematopoietic cells (Phd1f/fTie2:cre) protected mice from dextran sulphate sodium (DSS)‐induced colitis, with reduced epithelial erosions, immune cell infiltration, and colonic microvascular dysfunction.
37