Sarah C. Stapleton
University of Pennsylvania
6 Papers
24 Citations
Sarah C. Stapleton is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Mural cell & Role of cell adhesions in neural development. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Sarah C. Stapleton include Boston University.
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Papers
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro
Duc-Huy T. Nguyen,Sarah C. Stapleton,Michael T. Yang,Susie S. Cha,Colin K. Choi,Peter A. Galie,Christopher S. Chen +6 more
TL;DR: An in vitro 3D biomimetic model that reconstitutes the morphogenetic steps of angiogenic sprouting and neovessel formation is engineered and the potential utility of the model is highlighted to elucidate the molecular mechanisms that coordinate the complex series of events involved in neovascularization.
Myosin IIA–mediated forces regulate multicellular integrity during vascular sprouting
Christine Yoon,Colin K. Choi,Sarah C. Stapleton,Teodelinda Mirabella,Caroline Howes,Li Dong,Li Dong,Jessica M. King,Jinling Yang,Assad A. Oberai,Assad A. Oberai,Jeroen Eyckmans,Jeroen Eyckmans,Christopher S. Chen,Christopher S. Chen +14 more
TL;DR: A critical role for NMIIA-mediated contractile forces in maintaining multicellularity during sprouting is revealed and the central role of forces in regulating cell–cell adhesions during collective motility is highlighted.
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Force Measurement Tools to Explore Cadherin Mechanotransduction
TL;DR: This review will highlight the existing and emerging technologies and models that allow for exploration of cadherin-based adhesions as sites of mechanotransduction.
Patent
Microfabricated 3d cell culture system
Christopher S. Chen,Duc-Huy T. Nguyen,Sarah C. Stapleton,Michael T. Yang +3 more
- 01 Feb 2013
TL;DR: In this article, the authors proposed a 3D cell culture using an extracellular matrix including a substrate having at least one interior chamber, at least opening providing access to the interior chamber for introduction of an extacellular matrix, and at least channel disposed through at least a portion of the extra cellular matrix.
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Patterning vascular networks in vivo for tissue engineering applications.
Ritika Chaturvedi,Kelly R. Stevens,Ricardo D. Solorzano,Robert E. Schwartz,Jeroen Eyckmans,Jan D. Baranski,Sarah C. Stapleton,Sangeeta N. Bhatia,Christopher S. Chen +8 more
TL;DR: The design parameters of an approach for patterning the formation of functional spatially organized vascular architectures within engineered tissues in vivo are explored and important characteristics that will ultimately impact the design of vasculature structures that meet tissue-specific needs are defined.