Sara S. Parker
University of Arizona
17 Papers
61 Citations
Sara S. Parker is an academic researcher from University of Arizona. The author has contributed to research in topics: Biology & Cancer cell. The author has an hindex of 8, co-authored 14 publications.
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Papers
Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning
Adam W. Watson,Adam D. Grant,Sara S. Parker,Samantha M. Hill,Michael B. Whalen,Jayati Chakrabarti,Michael W. Harman,Mackenzie R. Roman,Brittany L. Forte,Cody C. Gowan,Raul Castro-Portuguez,Lindsey K. Stolze,Christian Franck,Darren A. Cusanovich,Yana Zavros,Megha Padi,Casey E. Romanoski,Ghassan Mouneimne +17 more
TL;DR: In this article, a multigenic score of mechanical conditioning (MeCo) was found associated with bone metastasis in patients with breast cancer, and the authors demonstrated that mechanical conditioning maintenance can be simulated, repressed, or extended, with corresponding changes in bone metastatic potential.
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Competing molecular interactions of aPKC isoforms regulate neuronal polarity
Sara S. Parker,Edward K. Mandell,Sophie M. Hapak,Irina Y. Maskaykina,Yael Kusne,Ji Young Kim,Jamie K. Moy,Paul A. St. John,Jean M. Wilson,Katalin M. Gothard,Theodore J. Price,Sourav Ghosh +11 more
TL;DR: A molecular model wherein mutually antagonistic intermolecular competition between aPKC isoforms directs the establishment of neuronal polarity is suggested, resulting in neurons with supernumerary axons.
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PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels
TL;DR: PKCι has an essential role in epithelial polarity and its knockdown increases epithelial barrier through control of the trafficking of claudin-2 through interaction with small GTPase Rab14.
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A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
Sarah Elizabeth Hurst,Erika Liktor-Busa,Aubin Moutal,Sara S. Parker,Sydney A. Rice,Szabolcs Szelinger,Grant D Senner,Michael F. Hammer,Laurel Johnstone,Keri Ramsey,Vinodh Narayanan,Samantha Perez-Miller,May Khanna,Heather R. Dahlin,Karen A. Lewis,David Craig,Edith H. Wang,Rajesh Khanna,Mark A. Nelson +18 more
- 28 Sep 2018
TL;DR: The genome of a 5-year-old male who presented with global developmental delay, hypotonia, possibly ataxia, and cerebellar hypoplasia of unknown origin is investigated, and a probable candidate variant, p.Ser1600Gly, emerged in TAF1, suggesting a key role in the development of a recently described X-linked syndrome, Taf1 intellectual disability syndrome.
Rabs set the stage for polarity.
TL;DR: The similarities and differences in Rab function for the instruction of polarity in diverse cell types are highlighted and several of the Rabs that impact polarity are present in the earliest eukaryotes.
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