Sara Mongiorgi
University of Bologna
59 Papers
261 Citations
Sara Mongiorgi is an academic researcher from University of Bologna. The author has contributed to research in topics: Azacitidine & Myelodysplastic syndromes. The author has an hindex of 19, co-authored 52 publications.
Chat about Author
Papers
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
Francesca Chiarini,M Del Sole,Sara Mongiorgi,Gc Gaboardi,Alessandra Cappellini,Irina Mantovani,My Follo,J A McCubrey,Am Martelli,Am Martelli +9 more
TL;DR: The findings indicate that perifosine is a promising therapeutic agent for treatment of T-ALL cases characterized by both upregulation of the PI3K/Akt survival pathway and overexpression of P-gp.
151
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
Matilde Y. Follo,Carlo Finelli,Cristina Clissa,Sara Mongiorgi,Costanza Bosi,Giovanni Martinelli,Michele Baccarani,Lucia Manzoli,Alberto M. Martelli,Lucio Cocco +9 more
TL;DR: PI-PLCbeta1 mono-allelic deletion is associated with a worse clinical outcome in MDS patients, hinting at the identification of a new group at higher risk of AML evolution and representing a reliable prognostic tool.
62
Nuclear Phosphoinositides: Their Regulation and Roles in Nuclear Functions
Roberta Fiume,Irene Faenza,Bhavwanti Sheth,Alessandro Poli,Magdalena Castellano Vidalle,Cristina Mazzetti,S. H. Abdul,Francesca Campagnoli,M. Fabbrini,Scott Kimber,Giulia Adalgisa Mariani,Jie Xian,Maria Vittoria Marvi,Sara Mongiorgi,Zahid H. Shah,Nullin Divecha +15 more
TL;DR: HowPPIns in the nucleus are modulated in response to external cues and how they function to control downstream signalling are discussed and a role for nuclear PPIns in liquid phase separations that are involved in the formation of membraneless compartments within the nucleus is suggested.
57
Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C
Alessandro Poli,Anna Maria Billi,Sara Mongiorgi,Stefano Ratti,James A. McCubrey,Pann-Ghill Suh,Lucio Cocco,Giulia Ramazzotti +7 more
TL;DR: The discovery of this mechanism shed new light on many nuclear functions, such as gene transcription, DNA modifications, and RNA expression, which are fundamental in the study of many cellular processes.
45
PI-PLCbeta-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes.
Matilde Y. Follo,Carlo Finelli,Costanza Bosi,Giovanni Martinelli,Sara Mongiorgi,Michele Baccarani,Lucia Manzoli,Wl Blalock,Alberto M. Martelli,Alberto M. Martelli,Lucio Cocco +10 more
TL;DR: PI-PLC β -1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes and further research is needed to establish a causative mechanism.
41