Sara D. Alvarez
University of California, San Diego
11 Papers
241 Citations
Sara D. Alvarez is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biosensor & Porous silicon. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Sara D. Alvarez include University of California.
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Papers
A label-free porous alumina interferometric immunosensor.
TL;DR: A "cascaded", or multiprobe sensing approach, is demonstrated, in which a specific target, sheep IgG, is administered to a sample modified with a protein A/rabbit anti-sheep IgG assembly, allowing quantitative monitoring of steady-state and time-resolved biomolecular binding.
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The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors.
TL;DR: The hydrosilylation chemistry greatly improves the stability of porous Si in contact with cultured primary cells while allowing cell coverage levels comparable to standard culture preparations on tissue culture polystyrene.
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Porous SiO2 interferometric biosensor for quantitative determination of protein interactions: binding of protein A to immunoglobulins derived from different species.
TL;DR: Both steady-state and time-dependent measurements yield equilibrium binding constants that are consistent with literature values, and Kinetic rate constants determined through nonlinear least-squares analysis are in agreement with protein A/IgG binding on a surface.
124
The smart petri dish: A nanostructured photonic crystal for real-time monitoring of living cells
TL;DR: It is demonstrated that exposure of hepatocytes to the toxins cadmium chloride or acetaminophen leads to morphology changes that cause a measurable increase in scattered intensity, demonstrating the potential of the technique as a complementary tool for cell viability studies.
Using a porous silicon photonic crystal for bacterial cell-based biosensing
TL;DR: In this paper, a method for non-invasively monitoring the growth and infection of Pseudomonas syringae bacteria using a 1-D porous silicon photonic crystal and a white-light source coupled to a CCD spectrometer is presented.
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