Santiswarup Singha
University of Calgary
25 Papers
27 Citations
Santiswarup Singha is an academic researcher from University of Calgary. The author has contributed to research in topics: Chemistry & Autoimmunity. The author has an hindex of 11, co-authored 20 publications. Previous affiliations of Santiswarup Singha include University of Calcutta.
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Papers
Expanding antigen-specific regulatory networks to treat autoimmunity
Xavier Clemente-Casares,Jesús Blanco,Jesús Blanco,Poornima Ambalavanan,Jun Yamanouchi,Santiswarup Singha,César Fandos,Sue Tsai,Jinguo Wang,Nahir Garabatos,Cristina Izquierdo,Smriti M. Agrawal,Michael B. Keough,V. Wee Yong,Eddie A. James,Anna Moore,Yang Yang,Thomas Stratmann,Pau Serra,Pere Santamaria,Pere Santamaria +20 more
TL;DR: Systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse models, leading to resolution of established autoimmune phenomena.
463
Nanoparticle-Based Immunotherapy for Cancer
TL;DR: The current status of nanoparticle-based immunotherapeutic strategies for the treatment of cancer are reviewed, ranging from antigen/adjuvant delivery vehicles (to professional antigen-presenting cell types of the immune system) to direct tumor antigen-specific T-lymphocyte-targeting compounds and their combinations thereof.
452
Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
Santiswarup Singha,Kun Shao,Yang Yang,Xavier Clemente-Casares,Patricia Solé,Antonio Clemente,Jesús Blanco,Qin Dai,Fayi Song,Shang Wan Liu,Jun Yamanouchi,Channakeshava Sokke Umeshappa,Roopa Hebbandi Nanjundappa,Pascal Detampel,Matthias Amrein,César Fandos,Robert L. Tanguay,Susan Newbigging,Pau Serra,Anmar Khadra,Warren C. W. Chan,Pere Santamaria +21 more
TL;DR: The engineering principles impacting biological activity are defined, a synthesis process yielding safe and stable compounds are detailed, and how these nanomedicines interact with cognate T cells are visualize.
138
Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines.
Channakeshava Sokke Umeshappa,Santiswarup Singha,Jesús Blanco,Kun Shao,Roopa Hebbandi Nanjundappa,Jun Yamanouchi,Albert Parés,Pau Serra,Yang Yang,Pere Santamaria +9 more
TL;DR: Autoreactivity against liver-enriched autoantigens in liver autoimmunity is not disease-specific and can be harnessed to treat various liver autoimmune diseases broadly, suggesting organ-wide tolerization.
Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction.
Arka Mukhopadhyay,Sankar Basu,Santiswarup Singha,Hirak K. Patra +3 more
- 05 Sep 2018
TL;DR: In this paper, a review of the mechanistic view of NM-protein interaction and recapitulate the underlying physical chemistry behind the formation of such complicated macromolecular assemblies, to provide a critical overview of different models describing NM induced structural and functional modification of proteins.