Sanjeev Kumar
Bryn Mawr College
23 Papers
119 Citations
Sanjeev Kumar is an academic researcher from Bryn Mawr College. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 10, co-authored 23 publications. Previous affiliations of Sanjeev Kumar include Dr. Reddy's Laboratories.
Chat about Author
Papers
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
Sanjeev Kumar,William P. Malachowski,James B. DuHadaway,Judith M. LaLonde,Patrick J. Carroll,Daniel Jaller,Richard Metz,George C. Prendergast,Alexander J. Muller +8 more
TL;DR: Genetic validation that IDO is the critical in vivo target is demonstrated using IDO-null mice and a new class of naphthoquinone-based IDO inhibitors exemplified by the natural product menadione is defined, shown in mouse tumor models to have similar antitumor activity to previously characterized IDO abusers.
170
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.
Sanjeev Kumar,Daniel Jaller,Bhumika Patel,Judith M. LaLonde,James B. DuHadaway,William P. Malachowski,George C. Prendergast,Alexander J. Muller +7 more
TL;DR: The study represents the first example of enzyme inhibitor development with the recently reported crystal structure of IDO and offers important lessons in the search for more potent inhibitors.
The synthesis and applications of asymmetric phase-transfer catalysts derived from isomannide and isosorbide
Sanjeev Kumar,Uma Ramachandran +1 more
TL;DR: In this article, the synthesis of various derivatives of isomannide and isosorbide is reported, and the effect of exo and endo substituents on the enantioselectivity of alkylation reaction have also been studied.
64
Pd/C-mediated coupling of aryl halides with terminal alkynes in water
Venkateswara Rao Batchu,Venkataraman Subramanian,Karuppasamy Parasuraman,Nalivela Kumara Swamy,Sanjeev Kumar,Manojit Pal +5 more
TL;DR: In this article, a variety of terminal alkynes were coupled with aryl iodides and bromides possessing no hydrophilic functional groups to give the coupled products in good to excellent yields.
53
Phase transfer catalyzed asymmetric alkylations of imine glycinamides
Sanjeev Kumar,Uma Ramachandran +1 more
TL;DR: The use of achiral imine glycinamides as substrates for asymmetric alkylations using chiral phase-transfer catalysts for the first time is reported.
19