Sangeetha P. Sumithran
University of Kentucky
13 Papers
183 Citations
Sangeetha P. Sumithran is an academic researcher from University of Kentucky. The author has contributed to research in topics: Nicotinic agonist & Nicotinic acetylcholine receptor. The author has an hindex of 10, co-authored 13 publications.
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Papers
Bupropion Inhibits Nicotine-Evoked [3H]Overflow from Rat Striatal Slices Preloaded with [3H]Dopamine and from Rat Hippocampal Slices Preloaded with [3H]Norepinephrine
TL;DR: Bupropion acts as an antagonist at α3β2∗ and α3 β4∗ nAChRs in rat striatum and hippocampus, respectively, across the same concentration range that inhibits DAT and NET function.
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QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release.
Fang Zheng,Ersin Bayram,Sangeetha P. Sumithran,Joshua T. Ayers,Chang-Guo Zhan,Jeffrey Daniel Schmitt,Linda P. Dwoskin,Peter A. Crooks +7 more
TL;DR: The application of the ANN QSAR model has led to the successful discovery of six new compounds in this study with experimental IC50 values of less than 0.1 microM at nAChR subtypes responsible for mediating nicotine-evoked dopamine release, demonstrating that the ANN SAR model is a valuable aid to drug discovery.
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Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
Xiaochen Wei,Sangeetha P. Sumithran,A. Gabriela Deaciuc,Harold R. Burton,Lowell P. Bush,Linda P. Dwoskin,Peter A. Crooks +6 more
TL;DR: A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers of 1,1'-dimethyl-[2,3']bipyrrolidsinyl were isolated from the root of Nicotiana tabacum plants and identified as novel alkaloids by GC-MS analysis.
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N,N′-alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked dopamine release and hyperactivity
Linda P. Dwoskin,Thomas E. Wooters,Sangeetha P. Sumithran,Kiran B. Siripurapu,B. Matthew Joyce,Paul R. Lockman,Vamshi K. Manda,Joshua T. Ayers,Zhenfa Zhang,Agripina G. Deaciuc,J. Michael McIntosh,Peter A. Crooks,Michael T. Bardo +12 more
TL;DR: Although none of the analogs altered the discriminative stimulus effect of nicotine, C8, C9, C10, and C12 analogs decreased nicotine-induced hyperactivity in nicotine-sensitized rats, without reducing spontaneous activity, suggesting brain bioavailability.
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Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Peter A. Crooks,Joshua T. Ayers,Rui Xu,Sangeetha P. Sumithran,Vladimir P. Grinevich,Lincoln H. Wilkins,A. Gabriela Deaciuc,David D. Allen,Linda P. Dwoskin +8 more
TL;DR: N-n-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release, and Conformationally restricted analogues exhibit both high affinity and selectivity at this site.
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